biomarker 1,698 words KG: complement
Contents

Complement Component 3 (C3)

🔬 Protein Info
Gene SymbolComplement
Chromosome19p13.3
Multiplex immunoassaysPlatforms such as Meso Scale Discovery (MSD) and Luminex allow simultaneous measurement of multiple complement components and cytokines, useful for profiling neuroinflammation[@lindblom2019].
Western BlotEnables detection of C3 cleavage products (C3a, C3b, C3c, C3d) to assess complement activation status.
Simoa (Single Molecule Array)Ultra-sensitive technology enabling detection of C3a in blood at concentrations below traditional ELISA limits[@song2021].
Mass SpectrometryTargeted proteomics can quantify C3 fragments with high specificity and is increasingly used in research settings.
Associated DiseasesALS, Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis
KG Connections1354 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (17)

Selective blockade of classical-pathway activation downstrea
Score: 0.75
Excessive C1q/C3/CR3 complement cascade activation initiates
Score: 0.72
Microglia and complement sustain post-Aβ neurodegeneration a
Score: 0.69
AQP4 Dysregulation Promotes Neuroinflammation Through Impair
Score: 0.68
Microglial TREM2 state determines whether C1q-tagged substra
Score: 0.67
LPS-primed microglial trained immunity establishes persisten
Score: 0.67
Peripheral-Central Immune Decoupling Therapy
Score: 0.66
C1q has spatially distinct functions, with synapse-bound C1q
Score: 0.63
APOE4-microglial complement signaling causes cholinergic-enr
Score: 0.63
Tau fibrils expose neuronal phosphatidylserine and heat-shoc
Score: 0.62
Female microglia exhibit heightened complement gene expressi
Score: 0.61
Synaptic protection via microglial/complement normalization
Score: 0.56
TREM2-complement-amyloid axis as therapeutic target for prot
Score: 0.55
Dysregulated microglial glycolysis via HIF1α activation shif
Score: 0.52
Complement Cascade Activation Bridges Microglial OxPC Sensin
Score: 0.42
Projection-specific vulnerability to complement-mediated syn
Score: 0.38
Rare TREM2-TYROBP pathway variants complement standard PRS b
Score: 0.38

Knowledge Graph (6 edges)

complement activates neurotoxicity
biomarkers-complement-c3 describes complement
h-6b9dec7170 targets complement
complement targeted_by h-6b9dec7170
complement regulates synaptic pruning
complement regulates developmental synaptic pruning

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