disease 2,602 words KG: ent-dise-7ac4ed37 2026-03-24
kind:diseasesection:diseasesstate:published
Contents

Hereditary Sensory and Autonomic Neuropathy (HSAN)

Disease Info
SPTLC1/2 mutationsAlter serine palmitoyltransferase activity, affecting lipid metabolism
TRPV1 mutationsImpair pain and temperature sensing channels
SCN9A/10A/11A mutationsAffect sodium channel function in pain signaling
NGF mutationsImpair neurotrophic support for sensory neurons
ELP1 mutationsAffect tRNA modification and transcriptional regulation
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.43

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Yoga Therapy for Neurodegeneration
therapeutic · Pages share 4 hypotheses
YAP/TEAD Pathway Modulators for Neurodegeneration
therapeutic · Pages share 4 hypotheses
Wnt Signaling Modulators for Neurodegeneration
therapeutic · Pages share 4 hypotheses
vitamin-d-therapy-neurodegeneration
therapeutic · Pages share 4 hypotheses
Vitamin B Complex Therapy for Neurodegeneration
therapeutic · Pages share 4 hypotheses