| Brainstem-predominant | Early motor symptoms of parkinsonism |
| Limbic | Psychiatric symptoms, emotional dysregulation |
| Cortical | Cognitive impairment, visual hallucinations |
| Post-translational modifications | Phosphorylation at Ser129, ubiquitination, nitration |
| Cellular stress | Oxidative stress, mitochondrial dysfunction, ER stress |
| Impaired clearance | Autophagy-lysosome and ubiquitin-proteasome system dysfunction |
| Dopaminergic | Loss of dopaminergic neurons in substantia nigra pars compacta, similar to Parkinson's disease |
| Cholinergic | Severe loss of cholinergic neurons in basal forebrain, more extensive than in AD |
| Serotonergic | Raphe nucleus involvement contributing to depression and anxiety |
| Noradrenergic | Locus coeruleus degeneration |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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