| Gene Symbol | ARF1 |
| Full Name | ADP Ribosylation Factor 1 |
| Protein Family | ARF GTPase family |
| Function | is a small GTP-binding protein that functions as a molecular switch regulating vesicle trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus. |
| Subcellular Localization | Golgi apparatus, ER-Golgi intermediate compartment |
| Molecular Weight | 20.7 kDa |
| Amino Acids | 181 aa |
| UniProt ID | [P84077](https://www.uniprot.org/uniprot/P84077) |
| GeneCards | ARF1 |
| Human Protein Atlas | ARF1 |
| N-terminal amphipathic helix | Myristoylated, anchors to membranes |
| Switch I region | Conformational change between GTP/GDP states |
| Switch II region | Critical for GTP hydrolysis |
| GTP-binding domains | N, K, and D loops for nucleotide coordination |
| COPI vesicle formation | Recruits coatomer complex to Golgi membranes |
| Associated Diseases | neurodegeneration |
| Interactions | Actin, AND, ASTROCYTE, ASTROCYTES, CANCER, Fus |
| SciDEX Hypotheses | LRP1-ARF1 Lactylation Inhibitors for Metabolic Neu |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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