| Gene Symbol | GCLC |
| Aliases | Glutamate-Cysteine Ligase Catalytic Subunit |
| Chromosome | 6p12.3 |
| Molecular Weight | 73 kDa |
| Amino Acids | 637 aa |
| Pathways | oxidative stress response, Oxidative Stress, Akt, Pi3K, Nf-Κb |
| Ensembl ID | ENSG00000001036 |
| GeneCards | GCLC |
| Human Protein Atlas | GCLC |
| Nrf2/ARE pathway | Primary transcriptional activator |
| AP-1 transcription factor | Induced by oxidative stress |
| NF-κB | Can both activate and repress depending on context |
| mRNA stability | Affected by redox state |
| Alternative splicing | Produces variant isoforms |
| Feedback inhibition | GSH inhibits GCLC activity |
| Associated Diseases | Alzheimer, Infection, Inflammation |
| Interactions | TNF, PI3K, NRF2, AKT, MYC, MTOR |
| KG Connections | 132 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |