| Gene Symbol | CHEK1 / CHECK1 |
| Full Name | Cell Cycle Checkpoint Kinase 1 |
| Aliases | CHK1, Cdc2-like 1 (CLK1) |
| Chromosome | 11q24.2 |
| Protein Type | Kinase |
| Function | Upon genotoxic insult, ATR phosphorylates CHECK1 at multiple sites—most critically at Ser317 and Ser345—triggering a conformational change that enables kinase activity[@global2023]. |
| Primary Expression | Ubiquitous; highest in brain, testis, thymus |
| Molecular Weight | ~54 kDa |
| Amino Acids | 433 aa |
| UniProt ID | O14757 |
| NCBI Gene ID | 1111 |
| Protein Name | Checkpoint kinase 1 protein |
| Protein Length | 433 amino acids |
| Protein Class | Serine/Threonine protein kinase |
| CDC25A | Ser123 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS |
| Databases | GeneCardsHPASTRING |