| Gene Symbol | CYP27A1 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | multiple tissues: |
| Molecular Weight | 60 kDa |
| Amino Acids | 503 aa |
| Pathways | Lipid Metabolism |
| Ensembl ID | ENSG00000135929 |
| GeneCards | CYP27A1 |
| Human Protein Atlas | CYP27A1 |
| Cholesterol 27-Hydroxylation | Catalyzes the first step in the alternative (27-hydroxyl) pathway of bile acid synthesis, converting cholesterol to 27-hydroxycholesterol (27-HC)[@bjorkhem2013] |
| Bile Acid Synthesis | Converts cholesterol to cholestenoic acid derivatives that are further processed to chenodeoxycholic acid and cholic acid |
| Oxysterol Production | Generates 27-hydroxycholesterol, a potent oxysterol that regulates LXR (Liver X Receptor) signaling and cholesterol homeostasis |
| Vitamin D Metabolism | Participates in the side-chain oxidation of vitamin D metabolites |
| Neurosteroid Synthesis | May contribute to neuroactive steroid formation in the brain |
| Associated Diseases | neurodegeneration |
| Interactions | CYP46A1, CYP7B1 |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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