gene 899 words KG: DDIT3 2026-03-24
kind:genesection:genesstate:published
Contents

DDIT3 Gene

🧬 Gene Info
Gene SymbolDDIT3
Full NameDDIT3
Chromosome12q24.1
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids169 aa
PathwaysAkt, Wnt
UniProt IDP35638
NCBI Gene ID1649
Ensembl IDENSG00000100994
GeneCardsDDIT3
Human Protein AtlasDDIT3
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsNBR1, EMD, MAPK8, RHOT1, BNIP3L, NDP52
KG Connections948 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49

Related Analyses (6)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

DDIT3 activates DISC1
DDIT3 activates DNM1L
DDIT3 activates DRP1
DDIT3 activates EIF2AK3
DDIT3 activates EIF2S1
DDIT3 activates EMD
DDIT3 activates EPAS1
DDIT3 activates FAM134B
DDIT3 activates FIP200
DDIT3 activates FMR1