gene 776 words KG: CTSD
Contents

CTSD — Cathepsin D

🧬 Gene Info
Gene SymbolCTSD
Full NameCathepsin D
AliasesCPSD, CLN10
Chromosome11p15.5
Protein TypeProtease
Functionis a lysosomal aspartic protease encoded by the CTSD gene.
Primary ExpressionBrain, liver, macrophages, neurons, microglia
Molecular Weight48 kDa
PathwaysAkt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt IDP07339
NCBI Gene ID1509
Ensembl IDENSG00000103811
GeneCardsCTSD
Human Protein AtlasCTSD
Pre-proenzymeSignal peptide + prosegment + mature enzyme
Associated DiseasesAD, ADH, Aging, ALI, Als
Known Drugs/CompoundsCHLOROQUINE, COENZYME Q10, H2S, rapamycin, RAPAMYCIN
InteractionsABCA1, ABCD3, ACTB, Actin, ADRA2A, AGING
SciDEX HypothesesCathepsin D Enhancement for Tau Degradation
KG Connections1554 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89
Noradrenergic-Tau Propagation Blockade
Score: 0.71
APOE-Dependent Autophagy Restoration
Score: 0.89
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
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Related Analyses (12)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

See Also (8)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABCD3 Gene
gene · KG edge: interacts_with
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: debate_co_mention
ACTB Gene
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

ACTB regulates CTSD
PPARA regulates CTSD
CAT regulates CTSD
SQSTM1 regulates CTSD
RPS6KB1 regulates CTSD
RAB7A regulates CTSD
SREBF1 regulates CTSD
EIF4EBP1 regulates CTSD
CTSD regulates PPARGC1A
CTSD regulates LRP2

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