gene 776 words KG: CTSD 2026-03-29
kind:genesection:genesstate:publishedtopic:parkinsonstopic:alzheimers
Contents

CTSD — Cathepsin D

🧬 Gene Info
Gene SymbolCTSD
Full NameCathepsin D
AliasesCPSD, CLN10
Chromosome11p15.5
Protein TypeProtease
Functionis a lysosomal aspartic protease encoded by the CTSD gene.
Primary ExpressionBrain, liver, macrophages, neurons, microglia
Molecular Weight48 kDa
PathwaysAkt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt IDP07339
NCBI Gene ID1509
Ensembl IDENSG00000103811
GeneCardsCTSD
Human Protein AtlasCTSD
Associated DiseasesAD, ADH, ALI, ALS, AMI, Aging
Known Drugs/CompoundsRAPAMYCIN, COENZYME Q10, rapamycin, CHLOROQUINE
InteractionsRB1, EIF2AK3, PRKN, BCL2L11, MUL1, BNIP3
KG Connections1566 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Noradrenergic-Tau Propagation Blockade
Score: 0.51
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (12)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CTSD activates EGFR
CTSD activates EIF4EBP1
CTSD activates LAMP1
CTSD activates LRP2
CTSD activates MAP1LC3B
CTSD activates MTOR
CTSD activates MYC
CTSD activates PIK3C3
CTSD activates PPARA
CTSD activates PPARG