gene 828 words KG: CD4 2026-03-24
kind:genesection:genesstate:published
Contents

CD4 Gene

🧬 Gene Info
Gene SymbolCD4
Chromosome12p13.31.
Protein FamilyImmunoglobulin superfamily
Protein TypeReceptor
FunctionBinding to MHC class II molecules on antigen-presenting cells
Molecular Weight~55 kDa (glycosylated)
PathwaysAmyloid, Apoptosis, Autophagy, Complement, Differentiation
UniProt IDP01730
NCBI Gene ID921
Ensembl IDENSG00000149257
GeneCardsCD4
Human Protein AtlasCD4
Gene NameCluster of Differentiation 4
AgentMechanism
Natalizumabα4-integrin blocker
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Autoimmune
Known Drugs/CompoundsFINGOLIMOD
InteractionsPRDM1, FOXP3, CD8, HMOX1, OCLN, MAF
KG Connections1025 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
AMBRA1 Gene
gene · KG edge: associated_with
ALDH1L1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CD4 contributes_to Dementia
CD4 treats RORC
CD4 regulates CD8
CD4 regulates FOXP3
CD4 expressed_in STAR
CD4 inhibits PRDM1
CD4 activates FOXP3
CD4 regulates DNAJB1
CD4 regulates JUN
CD4 associated_with CD8