gene 652 words KG: ERCC2 2026-03-22
kind:genesection:genesstate:published
Contents

ERCC2 Gene - Excision Repair Cross-Complementation Group 2

🧬 Gene Info
Gene SymbolERCC2
Full NameExcision Repair Cross-Complementation Group 2
AliasesPage for ERCC2 Gene, Page for ERCC2 Protein (XPD)
Chromosome19q13.32
Protein TypeTranscription Factor
FunctionIt functions as the 5' to 3' helicase subunit within the TFIIH complex (Core TFIIH).
Molecular Weight87 kDa
Amino Acids760 aa
UniProt IDP18080
NCBI Gene ID2075
Ensembl IDENSG00000104881
OMIM278720
GeneCardsERCC2
Human Protein AtlasERCC2
Associated DiseasesALS, Alzheimer
InteractionsCANCER
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.49
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.38
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Cross-Seeding Prevention Strategy
Score: 0.45

Related Analyses (12)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (8)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

ERCC2 associated_with APOE
ERCC2 activates CANCER
ERCC2 contributes_to AUTOPHAGY
ERCC2 associated_with Als
ERCC2 activates Cancer
ERCC2 contributes_to Neurodegeneration
ERCC2 contributes_to Autophagy
ERCC2 associated_with Alzheimer
ERCC2 expressed_in Als
ERCC2 expressed_in Aging