gene 778 words KG: NBR1 2026-03-22
kind:genesection:genesstate:published
Contents

NBR1 Gene

🧬 Gene Info
Gene SymbolNBR1
Full NameNeighbor of BRCA1 Gene 1
Chromosome17q21.31
Protein TypeReceptor
FunctionNBR1 is a selective autophagy receptor
Primary Expressionall brain cell types:
PathwaysAkt, Autophagy, Chaperone, Innate Immunity, Lysosomal Degradation
UniProt IDQ14596
NCBI Gene ID10327
Ensembl IDENSG00000132716
OMIM605085
GeneCardsNBR1
Human Protein AtlasNBR1
Cell TypeExpression Level
[Neurons](/entities/neurons)High
Associated DiseasesAD, ALI, ALS, AMI, Alzheimer
Known Drugs/Compoundsdimethyl fumarate, rapamycin
InteractionsG3BP1, TOLLIP, SQSTM1, NDP52, TAX1BP1, FUS
KG Connections1436 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (10)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: co_discussed
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

NBR1 activates OPTINEURIN
NBR1 activates SMCR8
NBR1 activates TOLLIP
NBR1 activates ULK1
NBR1 activates NLRP3
NBR1 activates PARL
NBR1 activates PERK
NBR1 activates PEX3
NBR1 activates PINK1
NBR1 activates PRKN