gene 1,359 words KG: GCAT
Contents

GCAT — Glycerol-3-Phosphate O-Acetyltransferase

🧬 Gene Info
Gene SymbolGCAT
Full NameGlycerol-3-Phosphate O-Acetyltransferase
Chromosome22q13.33
Protein TypeEnzyme
Functionencodes a mitochondrial enzyme that catalyzes the initial committed step in glycerolipid biosynthesis—the acylation of glycerol-3-phosphate to form lysophosphatidic acid (LPA)[@leung2004][@takeuchi...
Amino Acids471 aa
Exons9
UniProt IDQ9Y5K8
NCBI Gene ID55324
Ensembl IDENSG00000128283
OMIM608807
GeneCardsGCAT
Human Protein AtlasGCAT
Associated DiseasesAging, Als
KG Connections4 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (7)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (5)

Neurodegeneration
disease · KG edge: implicated_in
OTOF (Otoferlin)
gene · KG edge: associated_with
SNAP29 — Synaptosomal-Associated Protein 29
gene · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (4 edges)

SNAP29 associated_with GCAT
GCAT associated_with OTOF
GCAT associated_with Als
GCAT associated_with Aging

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