| Gene Symbol | HES1 |
| Aliases | HES-1, Hairy and Enhancer of Split 1, bHLHb3 |
| Chromosome | 3q29 |
| Protein Type | Transcription Factor |
| Function | encodes a 282-amino acid protein that functions as a transcriptional repressor, binding to specific DNA sequences known as E-box motifs (CANNTG) in the promoters of target genes. |
| Primary Expression | Broader |
| Amino Acids | 282 aa |
| Pathways | Notch signaling, notch |
| UniProt ID | Q04723 |
| NCBI Gene ID | 3280 |
| Ensembl ID | ENSG00000114315 |
| OMIM | 139605 |
| GeneCards | HES1 |
| Human Protein Atlas | HES1 |
| Gene Name | Hairy and Enhancer of Split 1 |
| Associated Diseases | neurodegeneration |
| Interactions | NESTIN, GFAP, SOD1, DLL4, OLIG2, PSEN1 |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsHPASTRING |