Contents

DLL4 Gene

🧬 Gene Info

Gene Symbol	DLL4
Full Name	Delta-Like 4
Chromosome	15q15.1
Function	is a critical Notch ligand that plays essential roles in vascular development, blood-brain barrier formation, and neural stem cell function.
Primary Expression	multiple tissues with particularly important roles in:
Amino Acids	685 aa
Pathways	Notch, Notch signaling
UniProt ID	[Q9NRF0](https://www.uniprot.org/uniprot/Q9NRF0)
Ensembl ID	ENSG00000128917
GeneCards	DLL4
Human Protein Atlas	DLL4
Tip cell specification	DLL4-Notch signaling is critical for tip cell formation during angiogenesis
Iterative signaling	DLL4 can undergo regulated intramembrane proteolysis (RIP)
Fringe modification	DLL4-Notch interactions are modulated by glycosyltransferases
Associated Diseases	disease, neuroinflammation
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, ASTROCYTE, ASTROCYTES, CANCER
KG Connections	112 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph