gene 597 words KG: MAPTHAPLOTYPES 2026-03-24
kind:genesection:genesstate:published
Contents

MAPT Haplotypes (H1/H2)

🧬 Gene Info
Gene SymbolMAPTHAPLOTYPES
AliasesMAPTHAPLOTYPES
FeatureH1 Haplotype
Genomic StructureNon-inverted (ancestral)
Population Frequency~75% (European)
4R Tau ExpressionUpregulated
Tauopathy RiskIncreased
SubhaplotypeKey Variants
H1ars246408 (A), rs2471738 (T)
H1brs246408 (G), rs2471738 (C)
H1c/H1Prs8070723, rs242557
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (20)

Glymphatic-Mediated Tau Clearance Dysfunction
Score: 0.55
Dual-Circuit Tau Vulnerability Cascade
Score: 0.50
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio
Score: 0.49
Cholinergic Basal Forebrain-Hippocampal Circuit Protection
Score: 0.49
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Rece
Score: 0.49

Related Analyses (2)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (24)

Plasma ATN biomarkers across AD continuum in Chilean cohort
clinical · proposed · Score: 0.95
Double depletion rescue experiment: tau and MAP6 co-depletio
exploratory · proposed · Score: 0.95
Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90
Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90
Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (2 edges)

MAPTHAPLOTYPES data_in benchmark_ot_ad_answer_key:MAPTHAPLOTYPES
benchmark_ot_ad_answer_key:MAPTHAPLOTYPES data_in MAPTHAPLOTYPES