gene 726 words KG: MPZ 2026-03-24
kind:genesection:genesstate:published
Contents

MPZ — Myelin Protein Zero

🧬 Gene Info
Gene SymbolMPZ
Full NameMyelin Protein Zero
Chromosome1q23.3
FunctionThe MPZ gene encodes myelin protein zero (also known as P0), a critical structural protein of the peripheral nervous system myelin sheath.
Primary ExpressionPeripheral nervous system, Schwann cells
UniProt IDP07846
NCBI Gene ID4240
Ensembl IDENSG00000156675
OMIM159440
GeneCardsMPZ
Human Protein AtlasMPZ
Symbol [@omim] MPZ [@uniprot] Full NameMyelin Protein Zero
Associated DiseasesCharcot-Marie-Tooth Disease, Dejerine-Sottas Syndrome
InteractionsPMP22, SHP-2, DAF-18, Arf proteins, MBP
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (4)

SOX10 Gene
gene · KG edge: interacts_with
PMP22 — Peripheral Myelin Protein 22
gene · KG edge: interacts_with
EGR2 Gene (Early Growth Response 2)
gene · KG edge: regulates
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

MPZ interacts_with PMP22
MPZ interacts_with SHP-2
MPZ interacts_with Src kinases
MPZ regulates DAF-2
MPZ interacts_with DAF-18
MPZ regulates Krox20
MPZ interacts_with Arf proteins
MPZ regulates Egr2
MPZ interacts_with Sox10
MPZ causes Dejerine-Sottas Syndrome