gene

SOX10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOX10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections
0Hypotheses
1Analyses
36Outgoing
15Incoming

Summary

SOX10 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, implicated in. Associated with Aging, Als, Bipolar. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSOX10
Chromosome22q13.1
Protein TypeTranscription Factor
Functionis a critical transcription factor for neural crest development and glial cell differentiation.
Amino Acids446 aa
Exons3
UniProt IDP56937
NCBI Gene ID6663
Ensembl IDENSG00000100146
GeneCardsSOX10
Human Protein AtlasSOX10
GeneFunction
MBPMyelin Basic Protein
PLP1Proteolipid Protein
PMP22Peripheral Myelin Protein
Associated DiseasesAls, Tumor
InteractionsFUS, GDNF, FGF2, CHAT, P53, AND
KG Connections51 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SOX10 — AlphaFold P56937 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SOX10 Gene

gene · 697 words

Oligodendrocytes

cell · 4838 words

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

mechanism · 3583 words

Remyelination in Neurodegeneration

mechanism · 3377 words

FA2H Gene

gene · 3327 words

Demyelination

mechanism · 3212 words

Pathway Diagram

graph TD
    SOX10["<b>SOX10</b>"]
    Diabetes{"Diabetes"}
    SOX10 -->|"activates"| Diabetes
    Aging{"Aging"}
    SOX10 -->|"activates"| Aging
    Obesity{"Obesity"}
    SOX10 -->|"activates"| Obesity
    Multiple_Sclerosis{"Multiple Sclerosis"}
    SOX10 -->|"activates"| Multiple_Sclerosis
    Ms{"Ms"}
    SOX10 -->|"activates"| Ms
    Tumor{"Tumor"}
    SOX10 -->|"activates"| Tumor
    Schizophrenia{"Schizophrenia"}
    SOX10 -->|"expressed in"| Schizophrenia
    Als{"Als"}
    SOX10 -->|"contributes to"| Als
    Bipolar{"Bipolar"}
    SOX10 -->|"expressed in"| Bipolar
    Depression{"Depression"}
    SOX10 -->|"expressed in"| Depression
    P53["P53"]
    SOX10 -->|"activates"| P53
    DISC1["DISC1"]
    SOX10 -->|"expressed in"| DISC1
    AGING["AGING"]
    AGING -->|"activates"| SOX10
    style SOX10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (36)

TargetRelationTypeStr
stem cellsexpressed_incell_type0.70
Diabetesactivatesdisease0.65
Agingactivatesdisease0.65
Obesityactivatesdisease0.65
Multiple Sclerosisactivatesdisease0.65

Incoming (16)

SourceRelationTypeStr
OVERVIEWassociated_withgene0.60
NESTINactivatesgene0.60
EGFactivatesgene0.60
TUBULINactivatesgene0.60
FUSactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found