gene

PMP22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PMP22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

27Outgoing

13Incoming

0Experiments

0Debates

Summary

PMP22 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, causes. Associated with ALS, Als, Dementia. Connected to 23 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PMP22
Full Name	Peripheral Myelin Protein 22
Chromosome	17p12
Function	The PMP22 gene encodes a 22-kDa tetraspan membrane protein that is a major component of peripheral nerve myelin.
Primary Expression	Peripheral nervous system, Schwann cells
UniProt ID	P60265
NCBI Gene ID	537
Ensembl ID	ENSG00000109099
OMIM	601097
GeneCards	PMP22
Human Protein Atlas	PMP22
Associated Diseases	Als, Charcot-Marie-Tooth Disease, disease, multiple sclerosis, Neuropathy
Interactions	AKT, MPZ, MTOR, NEURON, PI3K, PMP22 PROTEIN
KG Connections	40 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PMP22 — AlphaFold P60265 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PMP22 — Peripheral Myelin Protein 22

gene · 700 words

→

PMP22 Protein — Peripheral Myelin Protein 22

protein · 818 words

→

Pathway Diagram

graph TD
    PMP22["<b>PMP22</b>"]
    Neuropathy{"Neuropathy"}
    PMP22 -->|"associated with"| Neuropathy
    Als{"Als"}
    PMP22 -->|"associated with"| Als
    Parkinson{"Parkinson"}
    PMP22 -->|"expressed in"| Parkinson
    Dementia{"Dementia"}
    PMP22 -->|"expressed in"| Dementia
    ALS{"ALS"}
    PMP22 -->|"causes"| ALS
    PMP22 -->|"causes"| Neuropathy
    MTDNA["MTDNA"]
    PMP22 -->|"expressed in"| MTDNA
    MYELIN["MYELIN"]
    PMP22 -->|"causes"| MYELIN
    AND["AND"]
    PMP22 -->|"causes"| AND
    neurodegeneration["neurodegeneration"]
    PMP22 -->|"implicated in"| neurodegeneration
    MPZ["MPZ"]
    MPZ -->|"interacts with"| PMP22
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"expressed in"| PMP22
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"expressed in"| PMP22
    CD9["CD9"]
    CD9 -->|"expressed in"| PMP22
    style PMP22 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Charcot-Marie-Tooth Disease	implicated_in	disease	0.95
Charcot-Marie-Tooth Disease	causes	disease	0.95
Myelin Maintenance	involved_in	process	0.85
Neuropathy	causes	disease	0.75
ALS	causes	disease	0.65
Als	associated_with	disease	0.65
Neuropathy	associated_with	disease	0.65
Als	causes	disease	0.65
Parkinson	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
MTDNA	expressed_in	gene	0.60
TTR	causes	gene	0.60
Schwann cells	expressed_in	cell_type	0.60
multiple sclerosis	causes	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
multiple sclerosis	associated_with	disease	0.60
Mtor	inhibits	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
AKT	inhibits	gene	0.60
Differentiation	inhibits	pathway	0.60
MTOR	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
MYELIN	causes	gene	0.60
MYELIN	associated_with	concept	0.50
disease	causes	disease	0.50
PMP22 PROTEIN	inhibits	protein	0.50
Proteins	inhibits	protein	0.50

Incoming (13)

Source	Relation	Type	Str
MPZ	interacts_with	gene	0.90
PARKINSON'S DISEASE	expressed_in	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
AND	causes	gene	0.60
MYELIN	causes	gene	0.60
CD9	expressed_in	gene	0.60
PTEN	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
EGR2	causes	gene	0.60
MFN2	causes	gene	0.60
MPZ	causes	gene	0.60
CX32	causes	gene	0.60
GJB1	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity