| Gene Symbol | PHF8 |
| Full Name | PHD Finger Protein 8 |
| Chromosome | Xp11.22 |
| Function | encodes a histone demethylase that removes mono- and dimethyl groups from histone H3 at lysine 9 (H3K9me1/2), histone H3 at lysine 27 (H3K27me2), and histone H4 at lysine 20 (H4K20me1). |
| Amino Acids | 1024 aa |
| Pathways | Epigenetic |
| UniProt ID | [Q9UPP1](https://www.uniprot.org/uniprot/Q9UPP1) |
| Ensembl ID | ENSG00000172943 |
| GeneCards | PHF8 |
| Human Protein Atlas | PHF8 |
| PHD finger | N-terminal zinc finger domain that specifically recognizes H3K4me3 (the activating promoter mark), tethering PHF8 to active gene promoters |
| JmjC domain | Catalytic Jumonji C domain that uses Fe(II) and 2-oxoglutarate as cofactors to oxidatively demethylate histone lysine residues |
| C-terminal region | Contains nuclear localization signals and mediates interactions with transcription factors |
| At gene bodies | PHF8 demethylates H3K9me2 to prevent spreading of heterochromatic silencing from adjacent repressive domains into active genes. |
| Cell cycle regulation | PHF8 demethylates H4K20me1 during the G1-S transition, regulating DNA replication licensing and cell cycle progression. |
| Associated Diseases | neurodegeneration |
| Interactions | MTOR, AUTOPHAGY, AMYLOID |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |