| Gene Symbol | SMC3 |
| Full Name | Structural Maintenance of Chromosomes 3 |
| Aliases | Page for SMC3 |
| Function | The SMC3 ATPase head domain hydrolyzes ATP to drive conformational changes that regulate cohesin loading, translocation, and release from chromatin. |
| Ensembl ID | ENSG00000103052 |
| GeneCards | SMC3 |
| Human Protein Atlas | SMC3 |
| Loop extrusion | Generating topologically associating domains (TADs) that organize the genome into functional compartments |
| Enhancer-promoter contacts | Facilitating long-range regulatory interactions |
| Gene expression programs | Regulating activity-dependent neuronal gene expression[@rao2014] |
| Intellectual disability | Disrupted cohesin-mediated gene regulation |
| Autism spectrum disorder | Altered synaptic gene expression programs |
| Seizures | Aberrant neuronal network development[@gomperts2009] |
| Associated Diseases | Als |
| Interactions | HDAC8 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |