| Gene Symbol | SPPL2A |
| Chromosome | 15q21.3 |
| Protein Type | Protease |
| Function | encodes an intramembrane aspartyl protease that catalyzes the proteolytic cleavage of type II membrane proteins within their transmembrane domains. |
| Primary Expression | dopaminergic neurons of the substantia nigra, the brain region most affect |
| Molecular Weight | 69 kDa |
| Amino Acids | 617 aa |
| Pathways | Notch |
| UniProt ID | Q8TDS0 |
| NCBI Gene ID | 84888 |
| Ensembl ID | ENSG00000119774 |
| GeneCards | SPPL2A |
| Human Protein Atlas | SPPL2A |
| Active site residues | Conserved Asp-Thr-Ser-Leu (DTSL) motif in transmembrane domain VI |
| Y/D motif | Conserved tyrosine-aspartate pair in transmembrane domain VII |
| Associated Diseases | neurodegeneration |
| Interactions | AP4E1 |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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