SciDEX — NOTCH

graph TD
    NOTCH["NOTCH"] -->|"participates in"| CANCER["CANCER"]
    NOTCH["NOTCH"] -->|"regulates"| CANCER_1["CANCER"]
    NOTCH["NOTCH"] -->|"participates in"| CERVICAL_CANCER["CERVICAL CANCER"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Tumor["Tumor"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Cancer["Cancer"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Cardiovascular["Cardiovascular"]
    ENDOTHELIAL["ENDOTHELIAL"] -.->|"inhibits"| NOTCH["NOTCH"]
    MACROPHAGE["MACROPHAGE"] -.->|"inhibits"| NOTCH["NOTCH"]
    LRP1["LRP1"] -->|"regulates"| NOTCH["NOTCH"]
    DNA_DAMAGE["DNA DAMAGE"] -->|"regulates"| NOTCH["NOTCH"]
    style NOTCH fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (459)

Target	Relation	Type	Str
Progenitor Cell Fate Determination	regulates	process	0.95
Neuronal Subtype Differentiation	involved_in	process	0.90
CANCER	participates_in	disease	0.80
CANCER	regulates	disease	0.80
CERVICAL CANCER	participates_in	disease	0.80
Notch signaling	participates_in	pathway	0.80
apoptosis pathway	participates_in	pathway	0.70
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Infection	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Hepatitis	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Hepatitis	activates	disease	0.65
Fibrosis	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	activates	disease	0.65
Tumor	inhibits	disease	0.65
Aging	activates	disease	0.65
Tumor	associated_with	disease	0.65
Fibrosis	contributes_to	disease	0.65
Carcinoma	contributes_to	disease	0.65
Cancer	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
TUMOR	regulates	disease	0.65
T CELL	causes	cell_type	0.65
T CELLS	causes	cell_type	0.65
ULK1	inhibits	gene	0.65
STAT3	activates	gene	0.65
UBIQUITIN	contributes_to	gene	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (1144)

Source	Relation	Type	Str
SYNCRIP	regulates	gene	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.88
CANCER	promotes	disease	0.65
CANCER	targets	disease	0.65
ASTROCYTES	regulates	cell_type	0.65
ASTROCYTE	causes	cell_type	0.65
ASTROCYTES	causes	cell_type	0.65
ASTROCYTE	increases	cell_type	0.65
ASTROCYTES	sensitizes_to	cell_type	0.65
ASTROCYTE	reduces	cell_type	0.65
ASTROCYTES	reduces	cell_type	0.65
GFAP	reduces	gene	0.65
LRP1	ubiquitinates	gene	0.65
IL-6	phosphorylates	gene	0.65
ENDOTHELIAL	regulates	cell_type	0.65
CANCER	interacts_with	disease	0.65
DEMENTIA	associated_with	disease	0.65
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.65
FTD	associated_with	disease	0.65
NEURON	associated_with	cell_type	0.65
AMYLOID	associated_with	protein	0.64
ENDOTHELIAL	inhibits	cell_type	0.60
MACROPHAGE	inhibits	cell_type	0.60
LRP1	regulates	gene	0.60
GFAP	mediates	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
AND	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
NF-ΚB	interacts_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
ASTROCYTES	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
NESTIN	inhibits	gene	0.60
HES1	activates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
P16	therapeutic_target	gene	0.60
PI3K	associated_with	gene	0.60
AND	associated_with	gene	0.60
PDGF	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
WNT	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
GENES	associated_with	gene	0.60
TNF-Α	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
CD8	associated_with	gene	0.60
TREM2	activates	gene	0.60

Name	NOTCH
Key Genes/Proteins	SYNCRIP
Related Diseases	ALZHEIMER'S DISEASE, CANCER, CERVICAL CANCER, Tumor, Cancer
Related Pathways	Notch signaling, apoptosis pathway

NOTCH

Understanding Entity Pages

Wiki Pages (20)

HNRNPA2B1 Protein

Oligodendrocytes

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Niemann-Pick Disease Type C (NPC)

Amyloid Cascade Pathway

Pathway Diagram

Outgoing (459)

Incoming (1144)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)

NOTCH

Understanding Entity Pages

Wiki Pages (20)

HNRNPA2B1 Protein

Oligodendrocytes

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Niemann-Pick Disease Type C (NPC)

Amyloid Cascade Pathway

PEN2 Gene

IGF-1 Signaling Pathway in Neurodegeneration

Astrocytes

Cellular Reprogramming Therapies for Neurodegeneration

Notch Signaling Pathway in Neurodegeneration

FGF10 — Fibroblast Growth Factor 10

Neurogenesis

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

genetics

Meningeal Lymphatics

KRIT1 — Krev Interaction Trapped 1 (CCM1)

Neurogenesis and Neurodegeneration

PSEN2 — Presenilin 2

Remyelination in Neurodegeneration

PTCH2 Gene

Pathway Diagram

Outgoing (459)

Incoming (1144)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)