gene 1,293 words KG: SYNA
Contents

SYNA — Synapsin I

🧬 Gene Info
Gene SymbolSYNA
Full NameSynapsin I
Chromosome17q21.31
Functionis a neuronal phosphoprotein associated with the cytoplasmic surface of synaptic vesicles.
Primary ExpressionBrain (cortex, hippocampus, cerebellum), neurons
Subcellular Localizationpresynaptic terminals where it associates with the cytoplasmic surface of synaptic vesicles. [@takamori2006]
Amino Acids706 aa
UniProt IDP17600
NCBI Gene ID6853
Ensembl IDENSG00000135547
OMIM313440
GeneCardsSYNA
Human Protein AtlasSYNA
Synapsin Ia706 amino acids
Synapsin Ib669 amino acids (lacking domain E)
KG Connections19 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (177)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Smartphone-Detected Motor Variability Correction
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
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Related Analyses (30)

Synaptic pruning by microglia in early AD
neurodegeneration · completed
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (14)

Microglia
cell · KG edge: co_discussed
Neuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: co_discussed
Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: co_discussed
Microglia in Neurodegeneration
entity · KG edge: co_discussed

Knowledge Graph (12 edges)

TFEB binds_to SYNA
SYNA co_discussed SPP1
SYNA co_discussed DYSF
GNAL co_discussed SYNA
SYNA co_discussed C1QA
SYNA co_discussed GRN
SYNA co_discussed CTSB
COMPLEMENT CASCADE co_discussed SYNA
C1Q co_discussed SYNA
MICROGLIA co_discussed SYNA

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