| Gene Symbol | GRN |
| Full Name | Progranulin |
| Aliases | Gene profile: GRN |
| Chromosome | 17q21.31 |
| Protein Family | Granulin family |
| Function | Each granulin domain is approximately 90 amino acids with 12 conserved cysteine residues forming 6 disulfide bonds, creating a compact, stable structure[3]. |
| Primary Expression | Cerebral cortex, Hippocampus, Microglia, Substantia nigra |
| Subcellular Localization | Secreted; also localizes to lysosomes |
| Molecular Weight | ~90 kDa (secreted); 68 kDa (granulin domain) |
| Amino Acids | 593 aa |
| Pathways | Autophagy, Immune Response |
| UniProt ID | P28799 |
| NCBI Gene ID | 2896 |
| Ensembl ID | ENSG00000030582 |
| OMIM | 138945 |
| GeneCards | GRN |
| Human Protein Atlas | GRN |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer |
| Interactions | CTSB, SPP1, NFL, C1QA, C9ORF72, APOE |
| KG Connections | 805 knowledge graph edges |
| Databases | GeneCardsHPASTRING |