gene 2,154 words KG: DYSF 2026-03-26
kind:genesection:genesstate:published
Contents

DYSF — Dysferlin

🧬 Gene Info
Gene SymbolDYSF
Full NameDysferlin
Chromosome2p13.2
Functionis a human gene located on chromosome 2p13.
Primary ExpressionSkeletal muscle, Cardiac muscle, Brain, Spinal cord
Molecular Weight~237 kDa
Amino Acids080 aa
PathwaysExocytosis, Immune Response
UniProt IDO75923
NCBI Gene ID8291
Ensembl IDENSG00000131721
OMIM603009
GeneCardsDYSF
Human Protein AtlasDYSF
Protein Length2,080 amino acids
Associated DiseasesMs
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.40
SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (2)

Nation-wide NGS-based genetic screening of LGMD patients in
exploratory · proposed · Score: 0.95
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: co_discussed
NBR1 Gene
gene · KG edge: co_discussed
MUL1 Gene
gene · KG edge: co_discussed
FMR1 — Fragile X Messenger Ribonucleoprotein 1
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

DYSF associated_with ANXA2
DYSF co_discussed CARDIOVASCULAR
DYSF co_discussed INFECTION
DYSF co_discussed MUL1
DYSF co_discussed NBR1
DYSF co_discussed NLRP3
DYSF co_discussed FMR1
DYSF co_discussed OPTN
DYSF co_discussed OPTINEURIN
DYSF co_discussed PARL