gene 2,340 words KG: CTSB
Contents

CTSB Gene

🧬 Gene Info
Gene SymbolCTSB
Full NameCathepsin B
Chromosome8p23.1
Subcellular Localization| Compartment | Function |
Molecular Weight26 kDa
Amino Acids339 aa
Exons13
PathwaysAutophagy
UniProt IDP07846
NCBI Gene ID1508
Ensembl IDENSG00000164733
OMIM116810
GeneCardsCTSB
Human Protein AtlasCTSB
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, APOPTOSIS
Known Drugs/Compoundsrapamycin, tannic acid
InteractionsACTB, Actin, AGING, AIF1, AKT, ALS
SciDEX HypothesesSelective cathepsin B inhibition prevents cathepsi
KG Connections815 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (31)

APOE-Dependent Autophagy Restoration
Score: 0.89
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
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Related Analyses (12)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: activates
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CTSB activates C1QA
CTSB activates SPP1
CTSB activates GRN
STIP1 associated_with CTSB
LGALS3 associated_with CTSB
HSPA8 associated_with CTSB
MCOLN1 associated_with CTSB
SQSTM1 associated_with CTSB
SOD1 associated_with CTSB
BCL2 associated_with CTSB

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