gene 2,210 words KG: TMEM55B
Contents

TMEM55B — Transmembrane Protein 55B

🧬 Gene Info
Gene SymbolTMEM55B
Full NameTransmembrane protein 55B / Type 1 PtdIns-4,5-P2 4-phosphatase
Chromosome14q11.2
Functionis a gene on chromosome 14q11.
Primary ExpressionBrain, Substantia Nigra, lysosomal compartments
Subcellular Localizationendolysosomal membranes where it regulates phosphatidylinositol (PI) signaling and lysosomal function
Amino Acids277 aa
UniProt IDQ86T03
NCBI Gene ID90809
Ensembl IDENSG00000100889
OMIM609865
GeneCardsTMEM55B
Human Protein AtlasTMEM55B
Current SymbolPIP4P1 (Phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1)
ProteinPIP4P1 (277 aa, Type II transmembrane lysosomal protein)
Associated DiseasesAlzheimer's Disease, BMD
InteractionsWDR81, JIP4, LRRK2
KG Connections18 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Autophagosome Maturation Checkpoint Control
Score: 0.49
VCP-Mediated Autophagy Enhancement
Score: 0.41
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (6)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: phosphorylates
TFE3 Gene
gene · KG edge: activates
LDLR Gene
gene · KG edge: regulates
CTNS Gene
gene · KG edge: associated_with
TFEB (Redirect)
redirect · KG edge: upregulates

Knowledge Graph (12 edges)

TMEM55B associated_with BMD
TMEM55B associated_with PLEKHM1
TMEM55B associated_with ESCRT machinery
TMEM55B associated_with FLCN/FNIP complex
TMEM55B associated_with CTNS
TMEM55B associated_with V-ATPase complex
TMEM55B interacts_with WDR81
TMEM55B associated_with Alzheimer's Disease
TMEM55B participates_in oxidative stress response
TMEM55B regulates CTNS