WDR81

Understanding Entity Pages

This page aggregates everything SciDEX knows about WDR81: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

WDR81 encodes a WD repeat domain protein involved in neurodevelopment, cerebellar function, and autophagy. Mutations cause autosomal recessive cerebellar ataxia.

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graph TD
    WDR81["<b>WDR81</b>"]
    Cardiovascular{"Cardiovascular"}
    WDR81 -->|"expressed in"| Cardiovascular
    GNPTG["GNPTG"]
    WDR81 -->|"activates"| GNPTG
    GNAI2["GNAI2"]
    WDR81 -->|"expressed in"| GNAI2
    NOD2["NOD2"]
    WDR81 -->|"expressed in"| NOD2
    GNAS["GNAS"]
    WDR81 -->|"expressed in"| GNAS
    GNAI3["GNAI3"]
    WDR81 -->|"activates"| GNAI3
    Autophagy(["Autophagy"])
    WDR81 -->|"expressed in"| Autophagy
    Wnt(["Wnt"])
    WDR81 -->|"expressed in"| Wnt
    Akt(["Akt"])
    WDR81 -->|"expressed in"| Akt
    neurodegeneration["neurodegeneration"]
    WDR81 -->|"implicated in"| neurodegeneration
    AKT1["AKT1"]
    AKT1 -->|"expressed in"| WDR81
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| WDR81
    AKT["AKT"]
    AKT -->|"expressed in"| WDR81
    GNB1["GNB1"]
    GNB1 -->|"expressed in"| WDR81
    AMPD2["AMPD2"]
    AMPD2 -->|"activates"| WDR81
    ATG5["ATG5"]
    ATG5 -->|"expressed in"| WDR81
    MAVS["MAVS"]
    MAVS -->|"expressed in"| WDR81
    TBK1["TBK1"]
    TBK1 -->|"expressed in"| WDR81
    CLCN7["CLCN7"]
    CLCN7 -->|"activates"| WDR81
    RIPK2["RIPK2"]
    RIPK2 -->|"expressed in"| WDR81
    IFIH1["IFIH1"]
    IFIH1 -->|"expressed in"| WDR81
    GNAI1["GNAI1"]
    GNAI1 -->|"expressed in"| WDR81
    style WDR81 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0