gene 1,812 words KG: VGLUT1
Contents

VGLUT1 Gene

🧬 Gene Info
Gene SymbolVGLUT1
AliasesVesicular Glutamate Transporter 1
Chromosome19q13.33
Primary Expressionglutamatergic (excitatory) neurons
Molecular Weight62 kDa
Amino Acids560 aa
Exons12
PathwaysAmyloid, Apoptosis
Ensembl IDENSG00000177656
GeneCardsVGLUT1
Human Protein AtlasVGLUT1
Associated DiseasesISCHEMIA, epilepsy, neurodegeneration
InteractionsTAU, APOE, APOE4, VEGF, GFAP, SLC17A6
KG Connections197 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles
Score: 0.53
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
APOE-Dependent Autophagy Restoration
Score: 0.61
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56

Related Analyses (8)

Mechanistic validation of SEA-AD differential expression hyp
neurodegeneration · failed
Do these mechanistic hypotheses explain layer-specific synap
neurodegeneration · failed
Do these mechanistic hypotheses from the SEA-AD Atlas bundle
neurodegeneration · failed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

VGLUT1 associated_with LAMP1
VGLUT1 encoded_by SLC17A7
VGLUT1 localized_to SYNAPTIC_VESICLE
VGLUT1 pharmacological_target TRORILUZOLE
VGLUT1 activates TAU
VGLUT1 activates APOE
VGLUT1 activates APOE4
VGLUT1 activates VEGF
VGLUT1 activates GFAP
VGLUT1 associated_with VGLUT2