gene 706 words KG: VMAT2 2026-03-24
kind:genesection:genesstate:published
Contents

VMAT2 Gene

🧬 Gene Info
Gene SymbolVMAT2
Full NameVesicular Monoamine Transporter 2
Chromosome10q25.2
FunctionVMAT2 mediates vesicular uptake of monoamines
Primary Expressionall monoaminergic neurons (dopaminergic, serotonergic, noradrenergic)
Molecular Weight56 kDa
Amino Acids525 aa
Exons18
PathwaysAutophagy, Mapk, Mtor
NCBI Gene ID6844
Ensembl IDENSG00000165646
OMIM193001
GeneCardsVMAT2
Human Protein AtlasVMAT2
DrugMechanism
Associated DiseasesParkinson's disease
Known Drugs/Compoundslevodopa
InteractionsMTOR, NEURON, NEUROINFLAMMATION, NURR1, AUTOPHAGY, PARKINSON'S DISEASE
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.42
Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.41

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: activates
NURR1 Gene
gene · KG edge: activates
MTOR Gene
gene · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates

Knowledge Graph (12 edges)

VMAT2 activates MTOR
VMAT2 activates NEURON
VMAT2 activates NEUROINFLAMMATION
VMAT2 activates Neuroinflammation
VMAT2 activates Parkinson
VMAT2 activates Inflammation
VMAT2 activates Mtor
VMAT2 activates Autophagy
VMAT2 activates Mapk
VMAT2 expressed_in dopaminergic neurons