gene 1,561 words KG: YARS2 2026-03-25
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

YARS2 — Tyrosyl-tRNA Synthetase 2, Mitochondrial

🧬 Gene Info
Gene SymbolYARS2
Full NameTyrosyl-tRNA Synthetase 2, Mitochondrial
Chromosome12p11.21
Protein TypeMitochondrial aminoacyl-tRNA synthetase
Functionencodes a mitochondrial aminoacyl-tRNA synthetase (mtaaRS) that catalyzes the attachment of tyrosine to its cognate mitochondrial tRNA during mitochondrial translation.
Subcellular Localizationor stability
Molecular Weight~52 kDa
Amino Acids495 aa
Exons13
UniProt IDQ9Y2Z4
NCBI Gene ID51091
Ensembl IDENSG00000143398
OMIM613739
GeneCardsYARS2
Human Protein AtlasYARS2
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (11)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in