idea 1,722 words KG: ent-gene-a90f5952 2026-03-24
kind:ideakind:therapy-ideasection:ideasstate:published
Contents

VPS35 Retromer Pharmacological Chaperone

🔬 Protein Info
Gene Symbolent-gene-a90f5952
Primary ExpressionUbiquitous; critical in neurons due to extreme endosomal trafficking demand (synaptic vesicle recycling, receptor sorting)
Subcellular LocalizationEndosomal membrane; cycles between early endosomes, recycling endosomes, and trans-Golgi network
Primary TargetVPS35-VPS29 interface of the retromer cargo-selective complex
Target TypePharmacological chaperone / protein-protein interaction stabilizer
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph