| Gene Symbol | PARK2 |
| Aliases | PARKIN |
| Chromosome | 6q26 |
| Protein Type | Ligase |
| Function | Parkin is a cytosolic E3 ubiquitin ligase essential for mitochondrial maintenance and quality control. |
| Primary Expression | AD brain
- Parkin can degrade amyloid precursor protein (APP) fragments
- May affect tau phosphorylation through ubiquitin-dependent pathways[@burns20 |
| Pathways | Adaptive Immunity, Amyloid, Apoptosis, Autophagy, Cell Cycle |
| UniProt ID | O60260 |
| NCBI Gene ID | 5071 |
| Ensembl ID | ENSG00000185358 |
| GeneCards | PARK2 |
| Human Protein Atlas | PARK2 |
| Year | Finding |
| 1998 | PRKN mutations linked to autosomal recessive PD |
| 2006 | PINK1-Parkin pathway identified in mitophagy |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer'S Disease |
| Known Drugs/Compounds | DEFERIPRONE, epigallocatechin gallate, RAPAMYCIN, RESVERATROL, Lycopene, Canagliflozin |
| Interactions | FMR1, SNCA, FAM134B, LC3, EPAS1, MIRO1 |
| KG Connections | 2935 knowledge graph edges |
| Databases | GeneCardsHPASTRING |