protein 1,564 words KG: PIK3C3 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

PIK3C3 (VPS34) Protein

🔬 Protein Info
Gene SymbolPIK3C3
AliasesVPS34
Chromosome18q12.3
Protein FamilyClass III Phosphoinositide 3-kinase (PI3K3C)
Function PIK3C3 contributes to lysosomal biogenesis and function through its role in autophagosome-lysosome fusion. The protein interacts with the HOPS complex via VPS34-generated PI3P
Subcellular LocalizationCytosol, endosomal membrane, phagophore
Molecular Weight~100 kDa (887 aa)
Amino Acids887 aa
Exons32
PathwaysPI3K
UniProt IDQ8N3F7
Ensembl IDENSG00000055070
GeneCardsPIK3C3
Human Protein AtlasPIK3C3
Protein NamePIK3C3 / VPS34
Associated DiseasesAD, ADH, ALS, AMI, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsEGFR, PPARG, HSPA5, MAVS, FIP200, AMBRA1
KG Connections1124 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (19)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.46
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.46
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.46
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.46
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.46

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: activates
AMBRA1 Gene
gene · KG edge: activates
AKT1 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PIK3C3 regulates CELL_POLARITY
PIK3C3 regulates EGFR
PIK3C3 regulates PPARG
PIK3C3 regulates LAMP1
PIK3C3 regulates RUBCN
PIK3C3 regulates RPS6
PIK3C3 interacts_with EGFR
PIK3C3 interacts_with PPARG
PIK3C3 interacts_with HSPA5
PIK3C3 interacts_with MAVS