protein 626 words KG: VPS35 2026-03-28
kind:proteinsection:proteinsstate:publishedevidence:strongtopic:parkinsons
Contents

VPS35 Protein

🔬 Protein Info
Gene SymbolVPS35
Full NameVPS35
AliasesVacuolar Protein Sorting 35
Protein TypeProtein
FunctionCargo Recognition: Binds to transmembrane cargo proteins containing cytoplasmic sorting motifs
Molecular Weight91.6 kDa
Amino Acids796 aa
PathwaysWnt
UniProt IDSearch UniProt
GeneCardsVPS35
Human Protein AtlasVPS35
Associated DiseasesALS, Alzheimer, Alzheimer's Disease, Amyotrophic Lateral Sclerosis
InteractionsEIF4G1, GAIN, LRRK2, MITOCHONDRIA, PYROPTOSIS, LYSOSOME
KG Connections381 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Lysosomal Enzyme Trafficking Correction
Score: 0.49
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

VPS35 contributes_to LRRK2
VPS35 contributes_to PRKN
VPS35 contributes_to GBA1
VPS35 contributes_to PINK1
VPS35 contributes_to PARK7
VPS35 contributes_to SNCA
VPS35 associated_with LRRK2
VPS35 associated_with PINK1
VPS35 associated_with PARKIN
VPS35 associated_with DJ1