gene 753 words KG: IL17A
Contents

IL17A — Interleukin 17A

🧬 Gene Info
Gene SymbolIL17A
Full NameInterleukin 17A
Chromosome6p12.2.
Functionis a 155-amino acid secreted glycoprotein that forms disulfide-linked homodimers.
Primary Expressionnon-immune cells including neurons and glia
Amino Acids155 aa
PathwaysNF-κB pathway, MAPK pathway, TGF-β
UniProt ID[Q16552](https://www.uniprot.org/uniprot/Q16552)
Ensembl IDENSG00000112116
OMIM603250
GeneCardsIL17A
Human Protein AtlasIL17A
IL17RCco-receptor, especially highly expressed in non-immune cells including neurons and glia
NF-κB pathwayClassical pro-inflammatory signaling via IKK complex activation
MAPK pathwaysC/EBPβ, C/EBPδ, and AP-1 family transcription factors
Associated DiseasesSenescence
Known Drugs/Compoundshyperforin
InteractionsPARKIN, TNF, BMAL1, DNMT1
KG Connections19 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

IL17A inhibits BMAL1
IL17A activates DNMT1
IL17A inhibits PARKIN
IL17A involved_in Staphylococcus Aureus Infection
IL17A associated_with CFH
IL17A mediates Staphylococcus Aureus Infection
IL17A mediates myeloid cell immune response
IL17A activates TNF
IL17A associated_with IL3
IL17A associated_with IL9