gene 3,014 words KG: IL3 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammationtopic:hematopoiesis
Contents

IL3 (Interleukin 3)

🧬 Gene Info
Gene SymbolIL3
Full NameInterleukin 3
Chromosome5q31.1
Protein FamilyIL-3 cytokine family
Functionis a secreted cytokine with a characteristic four-helix bundle structure
Primary Expressionthe brain by neurons, astrocytes, microglia, and endothelial cells, where they participate in neuroinflammatory processes relevant to neurodegenerativ
Molecular Weight~17 kDa
Amino Acids152 aa
Exons5
UniProt IDP08700
NCBI Gene ID3562
Ensembl IDENSG00000164399
OMIM147740
GeneCardsIL3
Human Protein AtlasIL3
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsIL1B, GNAL, Rb, CAMKII, CCND1, CYTOKINES
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE-TREM2 Interaction Modulation
Score: 0.48
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.43

Related Analyses (7)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (5)

Packard Center for ALS Research
institution · KG edge: inhibits
IL1B Gene - Interleukin 1 Beta
gene · KG edge: inhibits
GNAL — Gαolf Subunit
gene · KG edge: inhibits
TNF (Redirect)
redirect · KG edge: inhibits
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (11 edges)

IL3 inhibits IL1B
IL3 inhibits GNAL
IL3 inhibits Rb
IL3 associated_with IL9
IL3 inhibits CAMKII
IL3 inhibits CCND1
IL3 inhibits CYTOKINES
IL3 inhibits IL8
IL3 inhibits Als
TNF inhibits IL3