| Gene Symbol | DNMT1 |
| Chromosome | 19p13.2<br> |
| Protein Type | Epigenetic Regulator |
| Target Class | Epigenetic Regulator |
| Function | DNMT1 maintains DNA methylation patterns by copying methylation from the parental DNA strand to the newly synthesized strand. |
| Mechanism of Action | Small molecule inhibitor of DNA methyltransferase activity |
| Primary Expression | all tissues with high expression in: - Developing brain (neurons and progenitors) - Adult hippocampus (CA1, dentate gyrus) - Cere |
| Druggability | Medium (0.52) |
| Clinical Stage | Approved |
| Molecular Weight | 183 kDa |
| Pathways | Differentiation, Epigenetic, Immune Response |
| UniProt ID | P26358 |
| NCBI Gene ID | 1785 |
| Ensembl ID | ENSG00000123091 |
| GeneCards | DNMT1 |
| Human Protein Atlas | DNMT1 |
| Associated Diseases | Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN |
| Interactions | AKT, amyotrophic lateral sclerosis, AND, APOPTOSIS, AUTOPHAGY, BAX |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | DNMT1-Targeting Antisense Oligonucleotide Reset DNMT1 Compensation Window During Synaptic Resilien DNMT1 Downregulation to Correct Genome-Wide Hypome (+2 more) |
| KG Connections | 447 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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