protein

DNMT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNMT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

443Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

DNMT1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with ALS, Aging, Als. Connected to 156 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	DNMT1
Chromosome	19p13.2<br>
Protein Type	Epigenetic Regulator
Target Class	Epigenetic Regulator
Function	DNMT1 maintains DNA methylation patterns by copying methylation from the parental DNA strand to the newly synthesized strand.
Mechanism of Action	Small molecule inhibitor of DNA methyltransferase activity
Primary Expression	all tissues with high expression in: - Developing brain (neurons and progenitors) - Adult hippocampus (CA1, dentate gyrus) - Cere
Druggability	Medium (0.52)
Clinical Stage	Approved
Molecular Weight	183 kDa
Pathways	Differentiation, Epigenetic, Immune Response
UniProt ID	P26358
NCBI Gene ID	1785
Ensembl ID	ENSG00000123091
GeneCards	DNMT1
Human Protein Atlas	DNMT1
Associated Diseases	ALS, ALZHEIMER'S DISEASE, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	RAPAMYCIN, rapamycin
Interactions	SNCA, HSPA1A, DKK1, DNMT3B, BDNF, MDM2
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	DNMT1-Targeting Antisense Oligonucleotide Reset
KG Connections	443 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: DNMT1 — PDB 3PTA Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNMT1["DNMT1"]
    DNMT1 -->|"inhibits"| BMAL1["BMAL1"]
    DNMT1 -->|"regulates"| Ms["Ms"]
    DNMT1 -->|"activates"| Carcinoma["Carcinoma"]
    DNMT1 -->|"expressed in"| Cancer["Cancer"]
    DNMT1 -->|"interacts"| Als["Als"]
    DNMT1 -->|"interacts"| Schizophrenia["Schizophrenia"]
    DNMT1 -->|"target for"| Aging["Aging"]
    DNMT1 -->|"regulates"| GENES["GENES"]
    h_782e55f6["h-782e55f6"] -->|"target for"| DNMT1
    h_74777459["h-74777459"] -->|"target for"| DNMT1
    RB1["RB1"] -->|"regulates"| DNMT1
    IL17A["IL17A"] -->|"activates"| DNMT1
    MAPK["MAPK"] -->|"activates"| DNMT1
    PDPK1["PDPK1"] -->|"regulates"| DNMT1
    CANCER["CANCER"] -->|"expressed in"| DNMT1
    RELN["RELN"] -->|"interacts"| DNMT1

Outgoing (318)

Target	Relation	Type	Str
BMAL1	inhibits	gene	0.90
CHKA	downregulates	gene	0.90
CHKB	downregulates	gene	0.90
epigenetic regulation	participates_in	pathway	0.85
Triple-Negative Breast Cancer	associated_with	disease	0.80
Estrogen Receptor	associated_with	protein	0.80
Cancer Stem Cells	associated_with	cell_type	0.80
CpG_methylation	methylates	epigenetic_mark	0.80
Carcinoma	activates	disease	0.75
Cancer	expressed_in	disease	0.75
Cancer	activates	disease	0.75
BMAL1	regulates	gene	0.70
AKT	activates	gene	0.70
DNMT3A	stabilizes	gene	0.70
UBIQUITIN	modifies	protein	0.70
EZH2	regulates	gene	0.70
GENES	regulates	gene	0.70
CANCER	activates	gene	0.70
Autophagy	activates	pathway	0.70
Epithelial-Mesenchymal Transition	activates	pathway	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
NEURODEGENERATION	treats	phenotype	0.70
NEURODEGENERATION	inhibits	phenotype	0.70
NEURON	causes	cell_type	0.70
SYNAPTIC PLASTICITY	protects_against	phenotype	0.70
neural stem cells	activates	cell_type	0.70
Spinal Muscular Atrophy	associated_with	disease	0.65
DNMT3A	regulates	gene	0.65
DNMT3A	associated_with	gene	0.65
neurodegeneration	regulates	disease	0.65
TET2	inhibits	gene	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Ms	regulates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Liver Cancer	expressed_in	disease	0.65
Carcinoma	causes	disease	0.65

Incoming (125)

Source	Relation	Type	Str
h-782e55f6	targets_gene	hypothesis	0.90
h-74777459	targets_gene	hypothesis	0.90
Arsenic	upregulates	compound	0.85
Thermal adaptation	upregulates	process	0.85
RB1	regulates	gene	0.80
h-782e55f6	targets	hypothesis	0.80
h-74777459	targets	hypothesis	0.80
NFKB	associated_with	gene	0.80
IL17A	activates	protein	0.70
PDPK1	regulates	gene	0.70
MAPK	activates	pathway	0.70
NEURONS	treats	cell_type	0.70
ACTB	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HTT	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
SETX	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
ALS4	associated_with	gene	0.60
SMN1	associated_with	gene	0.60
RELN	interacts_with	gene	0.60
PENK	expressed_in	gene	0.60
NCAM1	expressed_in	gene	0.60
KDM1A	therapeutic_target	gene	0.60
HDAC2	therapeutic_target	gene	0.60
P62	associated_with	gene	0.60
PTEN	activates	gene	0.60
BAX	activates	gene	0.60
SOX9	expressed_in	gene	0.60
GAIN	therapeutic_target	gene	0.60
GPX4	activates	gene	0.60
NOS3	contributes_to	gene	0.60
ACTB	activates	entity	0.60
ALS4	activates	entity	0.60
ATG7	activates	entity	0.60
BECN1	activates	entity	0.60
CXCL8	associated_with	gene	0.60
CD8	activates	gene	0.60
TFEB	associated_with	gene	0.60
VIM	associated_with	gene	0.60
ADRA2A	expressed_in	gene	0.60
DNMT3B	expressed_in	gene	0.60
ACTB	regulates	gene	0.60
ATG7	regulates	gene	0.60
BECN1	regulates	gene	0.60
CANCER	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DNMT1-Targeting Antisense Oligonucleotide Reset	0.359	neurodegeneration	Epigenetic clocks and biological aging i

Mentioning Analyses (2)

Scientific analyses that reference this entity

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.469

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Assessment of Out-of-Pocket Costs for Robotic Cancer Surgery in US Adults. [PMID:31940036]	Nabi J, Friedlander DF, Chen X, Cole AP,	JAMA Netw Open	2020	1
Multidisciplinary Approach to Interstitial Lung Diseases: Nothing Is Better than [PMID:32709146]	Vancheri C, Basile A	Diagnostics (Basel)	2020	1
Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus. [PMID:29887377]	Quinodoz SA, Ollikainen N, Tabak B, Pall	Cell	2018	1
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. [PMID:28319113]	Shen JP, Zhao D, Sasik R, Luebeck J, Bir	Nat Methods	2017	1
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation [PMID:20644199]	McKenna A, Hanna M, Banks E, Sivachenko	Genome Res	2010	1
Prevalence of clinical and radiographic signs of osteoarthrosis of the temporoma [PMID:20395464]	Schmitter M, Essig M, Seneadza V, Balke	Dentomaxillofac Radiol	2010	1
Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethy [PMID:41955111]	Tang S, Zong L, Ma S, Shang Y, Wei J et	Proc Natl Acad Sci U S A	2026	0
Disrupting the epigenetic alliance: structural insights and therapeutic strategi [PMID:40960568]	Kamel EM, Ali MAM, Allam AA, Ahmed NA, A	Functional & integrative genom	2025	0
Flow cytometry of DNMT1 as a biomarker of hypomethylating therapies. [PMID:38345160]	Woost PG, William BM, Cooper BW, Ueda Os	Cytometry. Part B, Clinical cy	2024	0
DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppres [PMID:38755637]	Liu Y, Sun Y, Yang J, Wu D, Yu S, Liu J,	Molecular cancer	2024	0
Bi-functional CpG-STAT3 decoy oligonucleotide triggers multilineage differentiat [PMID:39171140]	Wang D, Kaniowski D, Jacek K, Su YL, Yu	Molecular therapy. Nucleic aci	2024	0
A precise and efficient circular RNA synthesis system based on a ribozyme derive [PMID:37378451]	Cui J, Zhang L, Zhang Z, Luo X, Liu Y, L	Nucleic acids research	2023	0
Channel branching and zigzagging in negative cloud-to-ground lightning. [PMID:28615706]	["Jiang R", "Qie X", "Zhang H", "Liu M",	Scientific reports	2017	0
Sequential transcriptional waves direct the differentiation of newborn neurons i [PMID:26940868]	["Telley L", "Govindan S", "Prados J", "	Science (New York, N.Y.)	2016	0

DNMT1

Understanding Entity Pages

Summary

Wiki Pages (21)

DNMT1 Gene

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Alpha-Synuclein Aggregation Pathway

epigenetics-neurodegeneration

Epigenetic Changes in PSP

Arsenic Exposure and Alzheimer's Disease Mechanism

Adult Neurogenesis in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

CRISPR Gene Editing for Parkinson's Disease

SNCA — Alpha-Synuclein

NNMT Gene

PDLIM7 Epigenetic Activation in Parkinson's Disease

Sirtuin Modulators for Parkinson's Disease

PD Therapeutic Approaches Scorecard

Section 107: CRISPR-Based Therapies in CBS/PSP

Section 102: Proteostasis Network Dysregulation in CBS/PSP

Anle253b Tau Aggregation Inhibitor

LRRK2 Kinase-Targeting Therapies

Neurorestore Therapies for Parkinson's Disease

Autophagy Enhancers for PD