| Gene Symbol | CFH |
| Chromosome | 1q31.3 |
| Function | Factor H functions as the main soluble regulator of the alternative complement pathway |
| Amino Acids | 121 aa |
| Pathways | Complement, Autophagy, Akt, Phagocytosis, Mitochondrial Function |
| Ensembl ID | ENSG00000005381 |
| GeneCards | CFH |
| Human Protein Atlas | CFH |
| N-terminal domains (1-4) | Mediate decay-accelerating and cofactor activity |
| Central domains (5-7) | Bind C3b and C3d |
| C-terminal domains (18-20) | Mediate host surface recognition and attachment |
| Associated Diseases | Als, Alzheimer, Atherosclerosis, Heart Failure, Neurodegeneration, Senescence |
| Interactions | AKT2, TFE3, SIRT5, TFEB, TIMP1, TNF |
| KG Connections | 74 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |