concept

KISS1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KISS1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

23Outgoing

18Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	KISS1R
Key Genes/Proteins	GFAP, LIN28B, KISS1
Related Diseases	Idiopathic Central Precocious Puberty, Central Precocious Puberty, ICPP, Als, ALS
Related Pathways	Hypothalamic-Pituitary-Gonadal Axis, PGE2 synthesis, Epigenetic, Dna Methylation

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    KISS1R["KISS1R"]
    KISS1R -->|"coexpressed_with"| GFAP["GFAP"]
    KISS1R -->|"regulates"| PGE2_synthesis["PGE2 synthesis"]
    KISS1R -->|"risk_factor_for"| Idiopathic_Central_Precocious_["Idiopathic Central Precocious Puberty"]
    KISS1R -->|"regulates"| metabolic_stress_response["metabolic stress response"]
    KISS1R -->|"regulates"| Als["Als"]
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| KISS1R
    ASTROCYTE["ASTROCYTE"] -->|"expressed in"| KISS1R
    AND["AND"] -->|"expressed in"| KISS1R
    GFAP -.biomarker for.-> KISS1R
    KISS1["KISS1"] -->|"regulates"| KISS1R

Outgoing (23)

Target	Relation	Type	Str
GFAP	coexpressed_with	protein	0.95
Hypothalamic-Pituitary-Gonadal Axis	regulates	pathway	0.90
PGE2 synthesis	regulates	pathway	0.88
Idiopathic Central Precocious Puberty	associated_with	disease	0.85
Idiopathic Central Precocious Puberty	risk_factor_for	disease	0.85
Central Precocious Puberty	causes	disease	0.85
metabolic stress response	regulates	process	0.82
ICPP	associated_with	disease	0.80
Als	regulates	disease	0.65
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Epigenetic	associated_with	pathway	0.60
Dna Methylation	associated_with	pathway	0.60
LIN28B	associated_with	gene	0.60
KISS1	associated_with	gene	0.60
TAC3	associated_with	gene	0.60
DNA	associated_with	gene	0.60
DLK1	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
TACR3	associated_with	gene	0.60
GAIN	associated_with	gene	0.60
MKRN3	associated_with	gene	0.60
MKRN3	interacts_with	gene	0.60

Incoming (18)

Source	Relation	Type	Str
ASTROCYTES	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
GFAP	biomarker_for	gene	0.60
KISS1	regulates	gene	0.60
GENES	associated_with	gene	0.60
LIN28B	associated_with	gene	0.60
DNA	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
TACR3	associated_with	gene	0.60
MKRN3	associated_with	gene	0.60
GAIN	associated_with	gene	0.60
KISS1	associated_with	gene	0.60
TAC3	associated_with	gene	0.60
AND	associated_with	gene	0.60
DLK1	associated_with	gene	0.60
DLK1	interacts_with	gene	0.60
KISS1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KISS1R

Understanding Entity Pages

Wiki Pages (4)

kisspeptin-neurons

Gonadal Axis Neurons in Gonadotropin-Secreting Adenoma