Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KISS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | KISS1 |
| Key Genes/Proteins | KISS1R, TAC3, AND, DLK1 |
| Related Diseases | Idiopathic Central Precocious Puberty, Central Precocious Puberty, ICPP, Als, ALS |
| Related Pathways | Hypothalamic-Pituitary-Gonadal Axis, Epigenetic, Dna Methylation |
Knowledge base pages for this entity
graph TD
KISS1["KISS1"]
KISS1 -->|"risk_factor_for"| Idiopathic_Central_Precocious_["Idiopathic Central Precocious Puberty"]
KISS1 -->|"regulates"| Als["Als"]
KISS1 -->|"regulates"| KISS1R["KISS1R"]
ASTROCYTES["ASTROCYTES"] -->|"expressed in"| KISS1
ASTROCYTE["ASTROCYTE"] -->|"expressed in"| KISS1
AND["AND"] -->|"expressed in"| KISS1
GFAP["GFAP"] -.biomarker for.-> KISS1| Target | Relation | Type | Str |
|---|---|---|---|
| Hypothalamic-Pituitary-Gonadal Axis | regulates | pathway | 0.90 |
| Idiopathic Central Precocious Puberty | associated_with | disease | 0.85 |
| Idiopathic Central Precocious Puberty | risk_factor_for | disease | 0.85 |
| Central Precocious Puberty | causes | disease | 0.85 |
| ICPP | associated_with | disease | 0.80 |
| Als | regulates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| KISS1R | regulates | gene | 0.60 |
| TAC3 | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| DLK1 | associated_with | gene | 0.60 |
| KISS1R | associated_with | gene | 0.60 |
| Epigenetic | associated_with | pathway | 0.60 |
| Dna Methylation | associated_with | pathway | 0.60 |
| KISS1R | interacts_with | gene | 0.60 |
| MKRN3 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ASTROCYTES | expressed_in | gene | 0.60 |
| ASTROCYTE | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| GFAP | biomarker_for | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| LIN28B | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| TACR3 | associated_with | gene | 0.60 |
| MKRN3 | associated_with | gene | 0.60 |
| GAIN | associated_with | gene | 0.60 |
| DLK1 | associated_with | gene | 0.60 |
| KISS1R | associated_with | gene | 0.60 |
| TAC3 | associated_with | gene | 0.60 |
| DLK1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||