concept

LYC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections
7Hypotheses
8Analyses
12Outgoing
0Incoming
16Experiments

No summary available yet. View on Wiki →

💡 Concept Info
NameLYC
Key Genes/ProteinsAKT, BECN1, MAP1LC3, PINK1, PRKN
Related Pathwaysautophagy
Linked Hypotheses10 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

akt-protein

protein · 1305 words

Pathway Diagram

flowchart TD
    N0["LYC"]
    N1["AKT"]
    N0 -->|"inhibits"| N1
    N2["autophagy"]
    N0 -->|"activates"| N2
    N3["Renal Fibrosis"]
    N0 -->|"treats"| N3
    N4["Mitophagy"]
    N0 -->|"activates"| N4
    N5["BECN1"]
    N0 -->|"contributes to"| N5
    N6["MAP1LC3"]
    N0 -->|"contributes to"| N6

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 protein
    class N2 pathway
    class N3 disease
    class N4 process
    class N5 gene
    class N6 gene

Outgoing (12)

TargetRelationTypeStr
AKTinhibitsprotein0.90
autophagyactivatespathway0.90
Autophagyactivatesprocess0.90
AKTinhibitsprotein0.85
Renal Fibrosistreatsdisease0.85

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Dual-Phase Medium-Chain Triglyceride Intervention 0.506 neurodegeneration How do astrocyte-neuron metabolic intera
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat 0.505 neurodegeneration Perivascular spaces and glymphatic clear
Glycosaminoglycan Template Disruption Approach 0.464 neurodegeneration Protein aggregation cross-seeding across
Glycine-Rich Domain Competitive Inhibition 0.429 neurodegeneration TDP-43 phase separation therapeutics for
Glial Glycocalyx Remodeling Therapy 0.415 neurodegeneration 4R-tau strain-specific spreading pattern
Metabolic Reprogramming via Microglial Glycolysis Inhibition 0.385 neurodegeneration Synaptic pruning by microglia in early A
Pharmacological Enhancement of APOE4 Glycosylation 0.366 neurodegeneration APOE4 structural biology and therapeutic

Mentioning Analyses (8)

Scientific analyses that reference this entity

What are the specific PTM changes in synaptic vesicle proteins during early AD p

neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.552

Metabolomic signatures of neurodegeneration: metabolic reprogramming in aging br

metabolomics | 2026-04-16 | 0 hypotheses

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

endocrinology | 2026-04-13 | 2 hypotheses Top: 0.572

Which specific metabolic pathways in APOE4 microglia are causally linked to dysf

neurodegeneration | 2026-04-11 | 0 hypotheses

Do tau-containing vesicles exhibit distinct surface glycosylation patterns compa

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (16)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid validation Alzheimer's Disease 0.400 0.50 human proposed $2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur validation Neurodegeneration 0.400 0.50 cell_line proposed $130,000
Proposed experiment from debate on Perivascular spaces and glymphatic falsification Neurodegeneration 0.400 0.50 cell_line proposed $100,000
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FTD validation ALS 0.400 0.50 human proposed $2,730,000
FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation clinical Alzheimer's Disease 0.400 0.50 human proposed $6,550,000
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD validation ALS 0.400 0.50 human proposed $2,730,000
Environmental Exposure Causal Attribution in ALS — Experiment Design validation ALS 0.400 0.50 human proposed $3,000,000
ALS Progression Rate Heterogeneity — mechanism and biomarker predictor clinical ALS 0.400 0.50 human proposed $6,550,000
Protein Aggregation Kinetic Validation Results validation Neurodegeneration 0.400 0.50 in_silico proposed $120,000
TDP-43 PET Ligand Development for FTD and ALS clinical ALS 0.400 0.50 human proposed $6,550,000
FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutation Carriers validation ALS 0.400 0.50 human proposed $3,000,000
Frontal and Temporal Lobe Selective Vulnerability in FTD — Mechanisms validation Neurodegeneration 0.400 0.50 human proposed $3,000,000
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas falsification Neurodegeneration 0.400 0.50 cell_line proposed $80,000
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an falsification Neurodegeneration 0.400 0.50 cell_line proposed $100,000
Proposed experiment from debate on Microglia activate astrocytes via I falsification Neuroinflammation 0.400 0.50 cell_line proposed $80,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] Chua JP, De Calbiac H, Kabashi E, Barmad Autophagy 2022 2
TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382] Meneses A, Koga S, O'Leary J, Dickson DW Mol Neurodegener 2021 2
Protein transmission in neurodegenerative disease. [PMID:32203399] Peng C, Trojanowski JQ, Lee VM Nat Rev Neurol 2020 2
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] Yu CH, Davidson S, Harapas CR, Hilton JB Cell 2020 2
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591] Rusmini P, Cortese K, Crippa V, Cristofa Autophagy 2019 2
Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557] Sun B, Zhang A, Feng S, Jamali AW, Jia Z Int Immunopharmacol 2026 1
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352] Pesce NA, Seminara G, Giarrusso G, Tomas Adv Biol (Weinh) 2026 1
Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] Fang M, Zhou Y, He K, Lu Y, Tao F, Huang Mol Neurobiol 2025 1
Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376] Sun L, Wang X, Guan S, Zhang P, Chen D, FASEB J 2025 1
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014] Fontana F, Giannitti G, Marchesi S, Limo Int J Biol Sci 2024 1
AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289] Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh Mol Med 2024 1
Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic sc [PMID:38448448] Yang ZR, Suo H, Fan JW, Lv N, Du K, Ma T Nat Commun 2024 1
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p [PMID:39149513] Samaržija I, Lukiyanchuk V, Lončarić M, Front Cell Dev Biol 2024 1
NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] Fei Y, Huang X, Ning F, Qian T, Cui J, W Biomed Pharmacother 2024 1
Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576] Rho H, Terry AR, Chronis C, Hay N Cell Metab 2023 1
N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818] Zhai X, Kong N, Zhang Y, Song Y, Qin W, Autophagy 2023 1
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. [PMID:36754049] Hung ST, Linares GR, Chang WH, Eoh Y, Kr Cell 2023 1
Genetic regulation of post-translational modification of two distinct proteins. [PMID:35332118] Landini A, Trbojević-Akmačić I, Navarro Nat Commun 2022 1
Divergent Golgi trafficking limits B cell-mediated IgG sialylation. [PMID:35726710] Glendenning LM, Zhou JY, Reynero KM, Cob J Leukoc Biol 2022 1
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans. [PMID:34433968] Tsiantoulas D, Eslami M, Obermayer G, Cl Nature 2021 1