gene

PRKN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1684Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

PRKN is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 740 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PRKN
Full Name	Parkin RBR E3 Ubiquitin Protein Ligase
Chromosome	6q26
Protein Type	Ligase
Function	is a gene located on chromosome 6q26 that encodes an E3 ubiquitin ligase essential for mitochondrial quality control and mitophagy[@kitada1998].
Primary Expression	Substantia nigra, Striatum, Cortex, Heart, Skeletal muscle
Pathways	Autophagy, E3 Ligase Activity, Glycolysis, Mitophagy, Oxidative Stress
UniProt ID	O60260
NCBI Gene ID	5071
Ensembl ID	ENSG00000185348
OMIM	602544
GeneCards	PRKN
Human Protein Atlas	PRKN
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	Fumarate, FB231, nicotinamide, dimethyl fumarate, rapamycin
Interactions	BCL2L11, MUL1, BNIP3, DISC1, EIF2S1, RIPK3
KG Connections	1684 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRKN — AlphaFold O60260 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRKN["PRKN"] -->|"causes"| PD["PD"]
    PRKN["PRKN"] -->|"regulates"| NEMO["NEMO"]
    PRKN["PRKN"] -->|"encodes"| Parkin["Parkin"]
    PRKN["PRKN"] -->|"causes"| Parkinson_s_disease["Parkinson's disease"]
    PRKN["PRKN"] -->|"interacts"| Dementia["Dementia"]
    PRKN["PRKN"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    CAT["CAT"] -->|"interacts"| PRKN["PRKN"]
    OPTN["OPTN"] -->|"interacts"| PRKN["PRKN"]
    DNM1L["DNM1L"] -->|"interacts"| PRKN["PRKN"]
    CANX["CANX"] -->|"interacts"| PRKN["PRKN"]
    style PRKN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (887)

Target	Relation	Type	Str
Autophagy	activates	pathway	1.00
Mitophagy	regulates	pathway	1.00
MITOCHONDRIA	activates	gene	1.00
Parkinson Disease	risk_factor_for	disease	0.95
Mitochondrial Quality Control	regulates	process	0.95
NEMO	mediates	protein	0.95
PINK1-Parkin-Mediated Mitophagy	involved_in	pathway	0.95
Exogenous Mitochondria	degrades	process	0.95
Als	associated_with	disease	0.95
Cancer	activates	disease	0.95
Parkinson's Disease	risk_factor_for	disease	0.95
Parkinson's Disease	causes	disease	0.95
Parkinson's Disease	associated_with	disease	0.95
Parkinson's Disease	contributes_to	disease	0.95
Mitochondrial Dysfunction	regulates	process	0.95
Parkinson'S Disease	associated_with	disease	0.95
mitophagy	promotes	process	0.92
NEMO	associated_with	protein	0.90
mitochondrial quality control	regulates	pathway	0.90
outer mitochondrial membrane proteins	modifies	protein	0.90
selective autophagy	activates	pathway	0.90
Mitochondrial Biogenesis	involved_in	process	0.90
Damaged Mitochondria	targets	phenotype	0.90
Mitochondrial Localization	involved_in	process	0.90
E3 Ligase Activity	involved_in	mechanism	0.90
depolarization-induced mitophagy	promotes	process	0.90
Ubiquitination	mediates	process	0.90
Early Onset Parkinson's Disease	risk_factor_for	disease	0.90
mitochondrial homeostasis	associated_with	process	0.90
mitophagy	activates	pathway	0.90
Mitophagy	involved_in	process	0.90
Mitophagy	mediates	process	0.90
MITOCHONDRIA	mediates	cell_type	0.90
MITOPHAGY	mediates	process	0.90
autophagy pathway	participates_in	pathway	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
Parkinson'S Disease	risk_factor_for	disease	0.90
ALS	risk_factor_for	disease	0.90
PARKIN	associated_with	gene	0.90
Mitophagy	activates	pathway	0.90
ER-Mitochondria Contact Sites	modulates	mechanism	0.88
Autophagy	involved_in	process	0.88
Depolarization-Induced Mitophagy	involved_in	process	0.85
UBIQUITIN	upstream_of	protein	0.85
Energy Balance	regulates	process	0.85
Mitochondrial Quality Control	involved_in	pathway	0.85
Mitochondrial Homeostasis	protects_against	process	0.85
neuroprotection	protects_against	process	0.85
Parkinson	associated_with	disease	0.85
Neuroprotection	mediates	process	0.85

Incoming (797)

Source	Relation	Type	Str
PINK1	activates	gene	1.00
MITOPHAGY	regulates	gene	1.00
PINK1	associated_with	gene	1.00
Fumarate	inhibits	compound	0.95
MANF	binds_to	protein	0.95
Fumarate	modulates	compound	0.95
SRT2104	upregulates	drug	0.92
MANF	interacts_with	protein	0.90
Succination	modulates	process	0.90
MANF	activates	protein	0.90
PHB2	mediates	protein	0.90
Succination	targets	process	0.90
AMPK	activates	protein	0.90
AMPK	phosphorylates	protein	0.90
PARK2	associated_with	gene	0.90
MITOPHAGY	activates	gene	0.90
AUTOPHAGY	activates	gene	0.90
CANCER	activates	gene	0.90
BOK	binds	protein	0.85
PINK1	coexpressed_with	gene	0.85
protein oxidation	inhibits	process	0.85
TMX2	mediates	protein	0.85
SNCA	upregulates	gene	0.85
FB231	activates	compound	0.85
SIRT1	upregulates	protein	0.85
APOE	inhibits	gene	0.85
CKLF	upregulates	protein	0.85
PINK1	participates_in	gene	0.80
Lyc	upregulates	compound	0.80
MAP1LC3B	regulates	gene	0.80
Autophagy Activation	downregulates	process	0.80
Srt2104	upregulates	drug	0.80
serotonin	modulates	compound	0.80
ATP13A2	interacts_with	gene	0.80
DNAJC6	interacts_with	gene	0.80
FBXO7	interacts_with	gene	0.80
CKLF	contributes_to	protein	0.80
CKLF1	contributes_to	gene	0.80
PRKAA	activates	gene	0.80
SQSTM1	activates	gene	0.80
LRRK2	associated_with	gene	0.80
PINK1	regulates	gene	0.80
RAB7_protein	interacts_with	protein	0.80
GENES	associated_with	gene	0.80
PARKINSON	associated_with	gene	0.80
GABARAP	associated_with	gene	0.70
DNM1L	associated_with	gene	0.70
LC3	associated_with	gene	0.70
RB1	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PRKN

Understanding Entity Pages

Summary

Wiki Pages (21)

PRKN — Parkin RBR E3 Ubiquitin Protein Ligase

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Mitochondrial Quality Control

Mitophagy Pathway in Neurodegeneration

substantia-nigra

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Neuroprotection Strategies in Neurodegeneration

Gene-Mechanism-Therapy Causal Chains

DNA Damage Response in Parkinson's Disease

er-stress-neurodegeneration

Necroptotic Neurons

autophagy-lysosomal-alzheimers

dna-damage-repair

ubiquitin-proteasome-dysfunction-neurodegeneration

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Experiment: Multi-Ethnic PD GWAS

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease

mitochondrial-dynamics

FBXO7 — F-Box Protein 7

Alpha-Synuclein Propagation Mechanism