gene

AUTOPHAGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13827Connections

30Hypotheses

20Analyses

50Outgoing

50Incoming

13Experiments

20Debates

Summary

Autophagy is an evolutionarily conserved cellular degradation pathway that removes damaged organelles and misfolded proteins through lysosomal degradation. In neurodegeneration, autophagy dysfunction contributes to accumulation of toxic protein aggregates including amyloid-beta, tau, alpha-synuclein, and TDP-43. Key regulators include mTOR, AMPK, Beclin-1, and TFEB. Enhancing autophagy is a major therapeutic strategy for neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	AUTOPHAGY
Aliases	Autophagy-lysosomal pathway, Cellular self-eating
Function	Protein degradation; Organelle turnover; Quality control
Pathways	mTOR pathway, AMPK signaling, Beclin-1 complex
Autophagosome accumulation	Accumulation of immature autophagosomes suggests block in fusion with lysosomes
Amyloid interaction	Aβ peptides impair autophagic flux, creating a vicious cycle
Mitophagy defects	Reduced PINK1/Parkin-mediated mitophagy leads to mitochondrial dysfunction
LRRK2 mutations	G2019S LRRK2 impairs autophagosome formation
PINK1/Parkin pathway	Loss-of-function mutations cause mitophagy failure
GBA mutations	Glucocerebrosidase deficiency impairs lysosomal function
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	3-Methyladenine, BEVACIZUMAB, BPA, COENZYME Q10, CURCUMIN, Cyclocreatine
Interactions	6-OHDA, ABCA1, ABCD3, ABCG1, ABCG2, ACC
KG Connections	7512 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Autophagy Mechanisms

mechanism · 4866 words

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AUTOPHAGY

pathway · 554 words

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Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| CANCER["CANCER"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| AGING["AGING"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| NEURON["NEURON"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| MICROGLIA["MICROGLIA"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| LYSOSOME["LYSOSOME"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| MITOCHONDRIA["MITOCHONDRIA"]
    end
    subgraph Signaling["Signaling"]
        AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| AGING_1["AGING"]
        AUTOPHAGY["AUTOPHAGY"] -.->|"inhibits"| P62["P62"]
        AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| CANCER_2["CANCER"]
        MTORC1["MTORC1"] -.->|"inhibits"| AUTOPHAGY["AUTOPHAGY"]
        ULK1["ULK1"] -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
        AMPK["AMPK"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
        SIRT1["SIRT1"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
        ROS["ROS"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
        P62_3["P62"] -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    end
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style CANCER fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AGING fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AGING_1 fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style CANCER_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style LYSOSOME fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MITOCHONDRIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MTORC1 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ULK1 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AMPK fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SIRT1 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ROS fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style P62_3 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (6280)

Target	Relation	Type	Str
PINK1	associated_with	gene	1.00
Mitochondrial Function	activates	pathway	1.00
AMPK	regulates	gene	1.00
APOPTOSIS	activates	gene	1.00
MITOPHAGY	regulates	gene	1.00
Autophagy	interacts_with	pathway	1.00
BECN1	activates	gene	1.00
Lipid Metabolism	activates	pathway	1.00
Aging	regulates	disease	1.00
Aging	activates	disease	1.00
Autophagy	expressed_in	pathway	1.00
Mapk	activates	pathway	1.00
Nf-Κb	inhibits	pathway	1.00
Als	interacts_with	disease	1.00
Als	regulates	disease	1.00
Apoptosis	associated_with	pathway	1.00
LC3	activates	gene	1.00
Mitophagy	activates	pathway	1.00
Inflammasome	activates	pathway	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Lysosomal Degradation	activates	pathway	1.00
Diabetes	activates	disease	1.00
Neurodegeneration	inhibits	disease	1.00
BECLIN1	activates	gene	1.00
Autophagy	therapeutic_target	pathway	1.00
Inflammation	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Autophagy	inhibits	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Epigenetic	activates	pathway	1.00
ferroptosis	regulates	phenotype	1.00
Ferroptosis	associated_with	pathway	1.00
Diabetes	therapeutic_target	disease	1.00
Als	inhibits	disease	1.00
Huntington	activates	disease	1.00
APOPTOSIS	regulates	gene	1.00
Fibrosis	activates	disease	1.00
Apoptosis	regulates	pathway	1.00
Ferroptosis	activates	pathway	1.00
CANCER	regulates	gene	1.00
Pyroptosis	regulates	pathway	1.00
Cancer	regulates	disease	1.00
Obesity	activates	disease	1.00
Er Stress	activates	pathway	1.00
cancer	associated_with	disease	1.00
Cardiovascular	therapeutic_target	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Cancer	inhibits	disease	1.00
Neuroinflammation	activates	disease	1.00
Nf-Κb	regulates	pathway	1.00

Incoming (7547)

Source	Relation	Type	Str
LC3	inhibits	gene	1.00
Diabetes	activates	disease	1.00
Aging	activates	disease	1.00
Obesity	activates	disease	1.00
ERK	activates	gene	1.00
LC3B	activates	gene	1.00
SQSTM1	interacts_with	gene	1.00
Ischemia	regulates	disease	1.00
MAP1LC3B	activates	gene	1.00
PI3K	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Aging	inhibits	disease	1.00
Senescence	regulates	disease	1.00
AKT	inhibits	protein	1.00
LC3	interacts_with	gene	1.00
PTEN	activates	gene	1.00
LC3	activates	gene	1.00
AKT	regulates	protein	1.00
SQSTM1	activates	gene	1.00
PINK1	regulates	gene	1.00
Inflammation	regulates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
ULK1	regulates	gene	1.00
Als	inhibits	disease	1.00
SQSTM1	regulates	protein	1.00
BECN1	associated_with	gene	1.00
Parkinson	therapeutic_target	disease	1.00
TLR4	activates	protein	1.00
BECN1	regulates	gene	1.00
ULK1	activates	protein	1.00
SIRT1	activates	protein	1.00
ATG5	activates	protein	1.00
MTOR	activates	gene	1.00
mTORC1	inhibits	pathway	1.00
p62	activates	protein	1.00
PINK1	activates	gene	1.00
LC3	regulates	protein	1.00
STING	activates	protein	1.00
OVERVIEW	regulates	gene	1.00
TFEB	activates	protein	1.00
PARKIN	regulates	gene	1.00
PRKN	activates	protein	1.00
NRF2	activates	gene	1.00
ATG	regulates	gene	1.00
ATG7	activates	gene	1.00
BECN1	activates	gene	1.00
MTOR	regulates	protein	1.00
AMPK	therapeutic_target	gene	1.00

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE-Dependent Autophagy Restoration	0.895	neurodegeneration	Survival Analysis of AD Patient Cohorts:
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.865	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
J-protein co-chaperone system mediates selective autophagy t	0.831	protein-biochemistry	Do chaperones selectively recognize path
Autophagy-Lysosomal Pathway Dysfunction as a Unifying Proteo	0.820	neurodegeneration	Cross-disease neurodegeneration mechanis
C9ORF72 autophagy-lysosome collapse across ALS and FTD	0.816	multi	Cross-disease neurodegeneration mechanis

VCP-Mediated Autophagy Enhancement	0.787	neurodegeneration	Tau propagation mechanisms and therapeut
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	alzheimers	Circuit-level neural dynamics in neurode
Transcriptional Autophagy-Lysosome Coupling	0.777	neurodegeneration	Autophagy-lysosome pathway convergence a
TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, a	0.776	multi	Cross-disease neurodegeneration mechanis
TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle	0.772	neurodegeneration	How do different organelle-specific auto
p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor	0.768	molecular-biology	What is the optimal therapeutic window t
Circadian Clock-Autophagy Synchronization	0.763	neurodegeneration	Sleep disruption as cause and consequenc
LAMP2A-Mediated Autophagy Enhancement Blocks Alpha-Synuclein	0.745	neurodegeneration	Test
H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Gran	0.737	neurodegeneration	How do pathological stress granules tran
VCP/p97 ATPase mutations impair extraction of ubiquitinated	0.720	neurodegeneration	What are the neuron-specific effects of
C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Gra	0.717	neurodegeneration	How do pathological stress granules in n
TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Ca	0.703	neurodegeneration	What mechanisms underlie neuronal resist
Lysosomal Acidification Failure: Convergent GBA1/LAMP2A–medi	0.700	neurodegeneration	-
TFEB-Independent Autophagy Bypass	0.697	neurodegeneration	Does TFEB dysfunction cause neurodegener
mTORC1 Reactivation as Autophagy-Senescence Divergence Point	0.682	molecular-biology	What is the optimal therapeutic window t
Autophagy-Lysosomal Degradation of IBA1 in Stressed Microgli	0.681	neuroinflammation	What causes IBA1 low/negative microglia
GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator	0.659	molecular-biology	What is the optimal therapeutic window t
Radiation drives pericyte senescence through lysosome acidif	0.652	neurodegeneration	What specific autophagy pathways are def
p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle	0.649	neurodegeneration	How do different organelle-specific auto
H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seed	0.640	neurodegeneration	Entorhinal cortex layer II vulnerability
G3BP1 NTF2L Domain-Mediated mRNP Scaffold Creates Core Exclu	0.633	neurodegeneration	What determines the spatial organization
Autophagy-Senescence Axis Therapeutic Window	0.624	-	Senescent cell clearance as neurodegener
Glial-Autophagy-Senescence Coupling Defines CNS Therapeutic	0.614	molecular-biology	What is the optimal therapeutic window t
Mitophagy collapse via PINK1-PRKN is the primary autophagy l	0.614	neurodegeneration	What specific autophagy pathways are def
LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy	0.000	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (20)

Scientific analyses that reference this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387

Clinical Trial Landscaping for Alzheimer's Disease Therapeutics

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.629

Does LRRK2's role as a lysosomal volume sensor explain the pathogenic mechanism

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.666

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-15 | 0 hypotheses

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (13)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-NPC effects on astrocytes in vitro ICH model	exploratory	intracerebral hemorrhage	0.900	0.00	in vitro ICH cell culture mode	completed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A
AMPK knockdown validation experiment	exploratory	intracerebral hemorrhage	0.880	0.00	astrocyte cell culture	proposed	N/A
P2RY12-MTOR pathway interaction in VSMCs	exploratory	atherosclerosis	0.850	0.00	cultured VSMCs	proposed	N/A
iPSC-NPC transplantation in ICH animal model	validation	intracerebral hemorrhage	0.850	0.00	animal ICH model	proposed	N/A
Autophagy Enhancement Drug Screening for Neurodegeneration	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Macroautophagy Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Validate Mitochondria-Lysosome Contact Site Dysfunction in PD	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
MLCS Quantification in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammati [PMID:37678798]	Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang	Cell Mol Gastroenterol Hepatol	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and inv [PMID:35176466]	Zhang L, Liang B, Xu H, Gong Y, Hu W, Ji	J Ethnopharmacol	2022	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Obestatin controls the ubiquitin-proteasome and autophagy-lysosome systems in gl [PMID:28675664]	Cid-Díaz T, Santos-Zas I, González-Sánch	J Cachexia Sarcopenia Muscle	2017	1
PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum [PMID:41920736]	Wang Z, Jin N, Li X, Ma X, Feng Y, Yin K	Cell reports	2026	0
Replating Induces mTOR-Dependent Rescue of Protein Synthesis in Charcot-Marie-To [PMID:41876253]	Koenig J, McGuire A, Homedan Y, Alberhas	eNeuro	2026	0
S-equol promotes ferroptosis in triple negative breast cancer by coordinating NC [PMID:41925800]	Ni F, Huang Z, Cui Y, Huang P, Xue Z, Hu	Molecular and cellular biochem	2026	0
Mammalian lipophagy: process and function. [PMID:41681129]	Zhao R, Dai E, Kang R, Liu J, Klionsky D	Autophagy	2026	0
TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiqu [PMID:41921828]	["Xin Y", "Sun Y", "Pan E", "Li M", "Che	Free radical biology & medicin	2026	0
Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clin [PMID:41396614]	Brown CA, Mundada NS, Cousins KAQ, Sadeg	JAMA neurology	2026	0
Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from th [PMID:41324484]	Zhang J, Lu X, Li S, Wang T, Ahmad I et	Adv Sci (Weinh)	2026	0
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregul [PMID:41325866]	Zhang K, Sun S, Qiu H, Zhao H, Zhao H et	J Ethnopharmacol	2026	0
Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clin [PMID:41396614]	Brown CA, Mundada NS, Cousins KAQ, Sadeg	JAMA Neurol	2026	0
Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR a [PMID:41445190]	Li J, Li J, Chen K	Mol Ther	2026	0
Aberrant nuclear pore complex degradation contributes to neurodegeneration in VC [PMID:41475349]	Dubey SK, Chaubey D, Ikenaga C, Lin WW,	Neuron	2026	0
Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy [PMID:41479169]	Li Z, Yang X, Mao J, Zeng P, Qi Y et al.	Autophagy	2026	0
Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protei [PMID:41529091]	Liu Y, Sun Y, Song TY, Ni SY, Pu YS et a	Cancer Res	2026	0
Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017]	Aynaashe A, Kursula P	Amino Acids	2026	0

Debates (20)

Multi-agent debates referencing this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

completed · Rounds: 5 · Score: 0.50 · 2026-04-25

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

The abstract describes IBA1 low/negative microglia in individuals with liver dis

closed · Rounds: 4 · Score: 0.76 · 2026-04-21

The core debate question remains unresolved - whether intrinsic tau conformation

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The debate identified glycolytic shifts and mTOR disruption but couldn't disting

closed · Rounds: 4 · Score: 0.48 · 2026-04-21

What is the current clinical trial landscape for AD therapeutics, and which mech

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

The debate assumed that correcting APOE4's aberrant domain interactions would re

closed · Rounds: 4 · Score: 0.43 · 2026-04-20

The debate highlighted major safety concerns about blocking CXCL10, particularly

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Is the amyloid concentration in AD clinical trials rational given lecanemab's ap

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

While the study establishes LRRK2 as a lysosomal swelling sensor and notes that

closed · Rounds: 4 · Score: 0.85 · 2026-04-16

Related Research

Hypotheses and analyses mentioning AUTOPHAGY in their description or question text

AUTOPHAGY

Understanding Entity Pages

Summary

Wiki Pages (2)

Autophagy Mechanisms

AUTOPHAGY

Pathway Diagram

Outgoing (6280)

Incoming (7547)

Targeting Hypotheses (30)

Mentioning Analyses (20)

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

Clinical Trial Landscaping for Alzheimer's Disease Therapeutics

Does LRRK2's role as a lysosomal volume sensor explain the pathogenic mechanism

Does APOE4 drive tau propagation

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

Does structural 'normalization' of APOE4 domain interactions actually improve am

Which specific metabolic pathways in APOE4 microglia are causally linked to dysf

Do tau strains or regional cellular environments primarily drive PSP vs CBD path

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

What causes IBA1 low/negative microglia in liver disease and how does this affec

How does controlled lysosomal membrane permeabilization induce autophagy without

How do neurodegeneration gene expression patterns in SEA-AD differ from other po

What determines the optimal timing and dosing of ketogenic interventions for neu

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Protein aggregation cross-seeding across neurodegenerative diseases

Sleep disruption as cause and consequence of neurodegeneration

Experiments (13)

Related Papers (20)

Debates (20)

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

The abstract describes IBA1 low/negative microglia in individuals with liver dis

The core debate question remains unresolved - whether intrinsic tau conformation

The debate identified glycolytic shifts and mTOR disruption but couldn't disting

What is the current clinical trial landscape for AD therapeutics, and which mech

The debate assumed that correcting APOE4's aberrant domain interactions would re

The debate highlighted major safety concerns about blocking CXCL10, particularly

Is the amyloid concentration in AD clinical trials rational given lecanemab's ap

While the study establishes LRRK2 as a lysosomal swelling sensor and notes that

Related Research

VCP-Mediated Autophagy Enhancement

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Transcriptional Autophagy-Lysosome Coupling

TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, and PD-like proteotox

TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy

p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor

Circadian Clock-Autophagy Synchronization

LAMP2A-Mediated Autophagy Enhancement Blocks Alpha-Synuclein Propagation in Park

H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules

VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates

C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Granules

TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Cascade in Motor Neuro

TFEB-Independent Autophagy Bypass

mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker