gene

BECN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BECN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3055Connections

0Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

BECN1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with AD, ALI, ALS. Connected to 1696 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	BECN1
Function	BECN1 encodes beclin-1, a key regulator of autophagy—a cellular process for degrading and recycling damaged organelles, protein aggregates, and intracellular pathogens.
Subcellular Localization	** \| Cytoplasm, Golgi apparatus, endoplasmic reticulum, mitochondria \|
Molecular Weight	60 kDa
Pathways	Akt, Apoptosis, Autophagy, Car-T, Epigenetic
UniProt ID	Q9Y5P6
Ensembl ID	ENSG00000126581
GeneCards	BECN1
Human Protein Atlas	BECN1
ATG Protein Recruitment	BECN1 interacts with the ATG12-ATG5-ATG16L1 conjugation system, facilitating the lipidation of LC3 and the expansion of the autophagosome membrane.
Synaptic Function	Autophagy regulated by BECN1 is essential for synaptic vesicle recycling, neurotransmitter release, and synaptic plasticity. Disrupted autophagy leads to impaired neurotransmission and synaptic loss.
Axonal Transport	BECN1-containing autophagosomes undergo retrograde transport along axons, enabling long-range degradation of cargo in the soma. This process is essential for axonal homeostasis.
Neurogenesis	During neural development and in adult neurogenic niches, BECN1 regulates the balance between neural stem cell proliferation and differentiation through selective autophagy of specific substrates.
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	crocin, HCQ, Isorhapontigenin, nicotine, rapamycin, RAPAMYCIN
Interactions	ABCD3, ACAT1, ACETYL-COA, ACHE, ACOX1, ACTB
KG Connections	3054 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BECN1 — AlphaFold Q9Y5P6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BECN1["BECN1"] <-->|"interacts with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    BECN1["BECN1"] <-->|"interacts with"| Dementia["Dementia"]
    BECN1["BECN1"] <-->|"interacts with"| Als["Als"]
    BECN1["BECN1"] <-->|"interacts with"| Cardiovascular["Cardiovascular"]
    BECN1["BECN1"] <-->|"interacts with"| Alzheimer["Alzheimer"]
    BECN1["BECN1"] <-->|"interacts with"| Parkinson["Parkinson"]
    BECN1["BECN1"] <-->|"interacts with"| Ms["Ms"]
    BECN1["BECN1"] <-->|"interacts with"| Cancer["Cancer"]
    BECN1["BECN1"] -->|"regulates"| Fibrosis["Fibrosis"]
    BECN1["BECN1"] ---|"associated with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    BECN1["BECN1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    BECN1["BECN1"] ---|"associated with"| Ataxia["Ataxia"]
    style BECN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (2115)

Target	Relation	Type	Str
BECN1	encodes	protein	0.00
AUTOPHAGY	activates	pathway	1.00
MTOR	activates	gene	1.00
autophagy	associated_with	pathway	1.00
Ferroptosis	activates	pathway	1.00
Cancer	activates	disease	1.00
APOPTOSIS	associated_with	gene	1.00
SQSTM1	activates	gene	1.00
Autophagy	associated_with	pathway	1.00
P62	activates	gene	1.00
Autophagy	activates	pathway	1.00
Als	activates	disease	1.00
autophagy	regulates	process	1.00
Inflammation	activates	disease	1.00
autophagy	activates	pathway	1.00
Autophagy	regulates	pathway	1.00
PIK3C3	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
Autophagy	inhibits	pathway	1.00
CANCER	activates	gene	1.00
ATG	associated_with	gene	1.00
Apoptosis	activates	pathway	1.00
MTOR	associated_with	gene	1.00
AUTOPHAGY	inhibits	gene	1.00
Mtor	associated_with	pathway	1.00
LC3	activates	gene	0.98
RAPAMYCIN	activates	drug	0.95
Tumor	associated_with	disease	0.95
S-palmitoylation	substrate_of	process	0.95
autophagosome biogenesis	necessary_for	process	0.95
STEM CELLS	activates	cell_type	0.95
Tumor	activates	disease	0.95
Cancer	regulates	disease	0.95
Als	regulates	disease	0.95
CD19 CAR-T cell cytotoxicity resistance	promotes	phenotype	0.92
lipolysis	promotes	process	0.90
RNA	activates	gene	0.90
AUTOPHAGY INITIATION	regulates	process	0.90
cancer cell evasion from CAR-T cells	enables	process	0.90
MAP1LC3	regulates	gene	0.90
System Xc(-)	inhibits	complex	0.90
tibial nerve	expressed_in	brain_region	0.90
ER stress response	regulates	process	0.90
mitophagy	associated_with	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
SYSTEM XC-	inhibits	receptor	0.90
CD19 CAR-T cell cytotoxicity	protects_against	phenotype	0.90
Autophagosome Formation	involved_in	process	0.90
cardiac function	protects_against	phenotype	0.90
PtdIns3K complex	part_of	pathway	0.90

Incoming (940)

Source	Relation	Type	Str
BECN1	encodes	gene	0.00
AUTOPHAGY	activates	gene	1.00
ROS	activates	gene	1.00
AMPK	activates	gene	0.98
ATXN3	associated_with	gene	0.95
ESM1	regulates	protein	0.95
AMPK	phosphorylates	protein	0.95
PKD2	interacts_with	protein	0.92
Thermal Adaptation	upregulates	process	0.90
Acetylation	modulates	process	0.90
BCL2	associated_with	gene	0.90
LRPPRC	interacts_with	protein	0.90
Dopamine-Conjugated Extracellular Vesicles	upregulates	compound	0.90
paeoniflorin	contributes_to	drug	0.90
Autophagy	upregulates	process	0.90
IL-6	phosphorylates	entity	0.90
rapamycin	targets	drug	0.90
ULK1	phosphorylates	protein	0.90
KLF10	regulates	protein	0.88
VCP	interacts_with	protein	0.88
aging	inhibits	phenotype	0.85
RUBCNL	interacts_with	protein	0.85
Thermal adaptation	upregulates	process	0.85
LRRK2	impairs	gene	0.85
crocin	inhibits	drug	0.85
TFEB	upregulates	protein	0.85
LYPLAL1-DT	interacts_with	gene	0.85
curcumin	upstream_of	drug	0.85
GXN	binds_to	drug	0.85
nicotine	activates	drug	0.85
RUBCN	interacts_with	protein	0.85
CB13	upregulates	drug	0.83
ALZHEIMER'S DISEASE	associated_with	gene	0.82
ALS	activates	disease	0.82
BCL2	activates	gene	0.82
LYC	contributes_to	drug	0.80
CKLF	contributes_to	protein	0.80
AR	activates	gene	0.80
ATG	component_of	gene	0.80
CKLF1	contributes_to	gene	0.80
CKLF	upregulates	protein	0.80
ubiquitin	modifies	protein	0.80
caspases	inhibits	protein	0.80
MLKL	regulates	gene	0.80
CLOCK	regulates	gene	0.80
ACTB	regulates	gene	0.80
CUL3	inhibits	gene	0.80
MAP1LC3B	participates_in	gene	0.80
SQSTM1	participates_in	gene	0.80
VCP	associated_with	protein	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning BECN1 in their description or question text

No additional research found

BECN1

Understanding Entity Pages

Summary

Wiki Pages (6)

BECN1 Protein (Beclin-1)

Beclin 1 (BECN1)

BECN1 Protein

BECN1 Gene

Beclin-1 (BECN1) Neurons

BECN1 Gene

Pathway Diagram

Outgoing (2115)

Incoming (940)

Targeting Hypotheses (0)

Mentioning Analyses (6)

Microglial senescence in Alzheimer and Parkinson disease progression

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

Comparative epigenetic signatures across AD, PD, and ALS

Neuroinflammation resolution mechanisms and pro-resolving mediators

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Mechanistic role of APOE in neurodegeneration

Experiments (0)

Related Papers (0)

Debates (6)

Microglial senescence in Alzheimer and Parkinson disease progression

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

What are the shared DNA methylation age acceleration and histone modification pa

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Analysis question not specified

Related Research