gene

BECN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BECN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2944Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

BECN1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with AD, ALI, ALS. Connected to 1696 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BECN1
Full Name	Beclin-1
Chromosome	17q21.31
Function	BECN1 encodes beclin-1, a key regulator of autophagy—a cellular process for degrading and recycling damaged organelles, protein aggregates, and intracellular pathogens.
Molecular Weight	60 kDa
Pathways	Akt, Apoptosis, Autophagy, Car-T, Epigenetic
UniProt ID	Q9Y5P6
NCBI Gene ID	9451
Ensembl ID	ENSG00000126581
OMIM	604378
GeneCards	BECN1
Human Protein Atlas	BECN1
Compound	Status
Rapamycin	FDA approved (organ transplant)
Metformin	FDA approved (diabetes)
Associated Diseases	AD, ALI, ALS, AMI, Alzheimer
Known Drugs/Compounds	RAPAMYCIN, SORAFENIB, nicotine, crocin, HCQ, rapamycin
Interactions	C9ORF72, NBR1, G3BP1, TOLLIP, SQSTM1, NDP52
KG Connections	2944 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BECN1 — AlphaFold Q9Y5P6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BECN1["BECN1"] <-->|"interacts with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    BECN1["BECN1"] <-->|"interacts with"| Dementia["Dementia"]
    BECN1["BECN1"] <-->|"interacts with"| Als["Als"]
    BECN1["BECN1"] <-->|"interacts with"| Cardiovascular["Cardiovascular"]
    BECN1["BECN1"] <-->|"interacts with"| Alzheimer["Alzheimer"]
    BECN1["BECN1"] <-->|"interacts with"| Parkinson["Parkinson"]
    BECN1["BECN1"] <-->|"interacts with"| Ms["Ms"]
    BECN1["BECN1"] <-->|"interacts with"| Cancer["Cancer"]
    BECN1["BECN1"] -->|"regulates"| Fibrosis["Fibrosis"]
    BECN1["BECN1"] ---|"associated with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    BECN1["BECN1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    BECN1["BECN1"] ---|"associated with"| Ataxia["Ataxia"]
    style BECN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (2023)

Target	Relation	Type	Str
PIK3C3	associated_with	gene	1.00
SQSTM1	activates	gene	1.00
P62	activates	gene	1.00
MTOR	activates	gene	1.00
AUTOPHAGY	activates	pathway	1.00
Autophagy	regulates	pathway	1.00
Autophagy	associated_with	pathway	1.00
Als	activates	disease	1.00
Autophagy	activates	pathway	1.00
Cancer	activates	disease	1.00
Ferroptosis	activates	pathway	1.00
Inflammation	activates	disease	1.00
Autophagy	inhibits	pathway	1.00
AUTOPHAGY	associated_with	gene	1.00
APOPTOSIS	associated_with	gene	1.00
CANCER	activates	gene	1.00
Mtor	associated_with	pathway	1.00
Apoptosis	activates	pathway	1.00
AUTOPHAGY	inhibits	gene	1.00
ATG	associated_with	gene	1.00
LC3	activates	gene	0.98
autophagosome biogenesis	necessary_for	process	0.95
S-palmitoylation	substrate_of	process	0.95
Tumor	associated_with	disease	0.95
Tumor	activates	disease	0.95
Cancer	regulates	disease	0.95
Als	regulates	disease	0.95
RAPAMYCIN	activates	drug	0.95
STEM CELLS	activates	cell_type	0.95
CD19 CAR-T cell cytotoxicity resistance	promotes	phenotype	0.92
Autophagy	involved_in	process	0.91
autophagy	activates	pathway	0.90
autophagy	associated_with	pathway	0.90
cardiac function	protects_against	phenotype	0.90
CD19 CAR-T cell cytotoxicity	protects_against	phenotype	0.90
SLC7A11	inhibits	protein	0.90
System X(c)(-)	associated_with	pathway	0.90
UBIQUITIN	activates	gene	0.90
LC3	upregulates	entity	0.90
SYSTEM XC-	inhibits	receptor	0.90
Autophagosome Formation	involved_in	process	0.90
autophagy	promotes	process	0.90
tibial nerve	expressed_in	brain_region	0.90
ER stress response	regulates	process	0.90
cancer cell evasion from CAR-T cells	enables	process	0.90
lipolysis	promotes	process	0.90
VPS15	interacts_with	protein	0.90
AUTOPHAGY INITIATION	regulates	biological_process	0.90
System Xc(-)	inhibits	complex	0.90
SYSTEM X(C)(-)	inhibits	process	0.90

Incoming (921)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	1.00
ROS	activates	gene	1.00
AMPK	activates	gene	0.98
ESM1	regulates	protein	0.95
ATXN3	associated_with	gene	0.95
AMPK	phosphorylates	protein	0.95
PKD2	interacts_with	protein	0.92
paeoniflorin	contributes_to	drug	0.90
LRPPRC	interacts_with	protein	0.90
Dopamine-Conjugated Extracellular Vesicles	upregulates	compound	0.90
ULK1	phosphorylates	protein	0.90
Acetylation	modulates	process	0.90
Thermal Adaptation	upregulates	process	0.90
IL-6	phosphorylates	entity	0.90
Autophagy	upregulates	process	0.90
rapamycin	targets	drug	0.90
VCP	interacts_with	protein	0.88
KLF10	regulates	protein	0.88
TFEB	upregulates	protein	0.85
RUBCN	interacts_with	protein	0.85
GXN	binds_to	drug	0.85
curcumin	upstream_of	drug	0.85
nicotine	activates	drug	0.85
crocin	inhibits	drug	0.85
LYPLAL1-DT	interacts_with	gene	0.85
Thermal adaptation	upregulates	process	0.85
aging	inhibits	phenotype	0.85
RUBCNL	interacts_with	protein	0.85
CB13	upregulates	drug	0.83
BCL2	activates	gene	0.82
ALZHEIMER'S DISEASE	associated_with	gene	0.82
ALS	activates	disease	0.82
CLOCK	regulates	gene	0.80
caspases	inhibits	protein	0.80
MLKL	regulates	gene	0.80
ubiquitin	modifies	protein	0.80
SQSTM1	participates_in	gene	0.80
CUL3	inhibits	gene	0.80
MAP1LC3B	participates_in	gene	0.80
JNK	upstream_of	protein	0.80
HCQ	modulates	drug	0.80
VCP	associated_with	protein	0.80
ACTB	regulates	gene	0.80
AR	activates	gene	0.80
CKLF	contributes_to	protein	0.80
LYC	contributes_to	drug	0.80
CKLF1	contributes_to	gene	0.80
ATG	component_of	gene	0.80
CKLF	upregulates	protein	0.80
SLC7A11	activates	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BECN1

Understanding Entity Pages

Summary

Wiki Pages (21)

BECN1 Gene

Gene-Mechanism-Therapy Causal Chains

FOXO1 Protein

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

TGF-β Signaling in Parkinson's Disease

bbb-transport-mechanisms

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

ftd-tdp43-pathway

Oxidative Stress in Neurodegeneration

Autophagy-Lysosomal Pathway in Parkinson's Disease

Beclin-1 Protein

GLP-1 Signaling Pathway in Neurodegeneration

MAP1LC3A Gene

autophagy-lysosomal-impairment-comparison

Autophagy-Lysosomal Pathway

autophagy-lysosomal-ad

mTOR Signaling in Parkinson's Disease

Proteostasis Network in Neurodegeneration

Autophagy-Lysosome Pathway in Neurodegeneration

fip200

LRPPRC Protein