gene

MAP1LC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1380Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

MAP1LC3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALI, ALS. Connected to 612 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	MAP1LC3
Pathways	Autophagy
GeneCards	MAP1LC3
Human Protein Atlas	MAP1LC3
Associated Diseases	AD, ALI, ALS, AMI, ARM
Known Drugs/Compounds	rapamycin, statins, dimethyl fumarate
Interactions	PI3K, LOX, MTOR, AKT, AMPK, SQSTM1
KG Connections	1378 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MAP1LC3["MAP1LC3"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    MAP1LC3["MAP1LC3"] -->|"interacts"| Als["Als"]
    MAP1LC3["MAP1LC3"] -->|"interacts"| Dementia["Dementia"]
    MAP1LC3["MAP1LC3"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MAP1LC3["MAP1LC3"] -->|"associated"| Glioblastoma["Glioblastoma"]
    MAP1LC3["MAP1LC3"] -->|"associated"| Tumor["Tumor"]
    LYC["LYC"] -->|"increases risk"| MAP1LC3["MAP1LC3"]
    ATG5["ATG5"] -->|"interacts"| MAP1LC3["MAP1LC3"]
    SQSTM1["SQSTM1"] -->|"interacts"| MAP1LC3["MAP1LC3"]
    SQSTM1_1["SQSTM1"] -->|"associated"| MAP1LC3["MAP1LC3"]
    style MAP1LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (753)

Target	Relation	Type	Str
LC3	activates	gene	1.00
LC3	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
SQSTM1	binds	protein	0.90
Autophagy	involved_in	process	0.90
autophagy	regulates	process	0.90
autophagy	biomarker_for	process	0.90
ULK1	activates	gene	0.90
SQSTM1	regulates	gene	0.90
ULK1	regulates	gene	0.90
oxidative stress response	participates_in	pathway	0.90
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
Cancer	associated_with	disease	0.85
Autophagy	biomarker_for	process	0.85
RNA	activates	gene	0.80
frontotemporal dementia	activates	disease	0.80
RNA	regulates	gene	0.80
STX17	regulates	gene	0.80
STX17	activates	gene	0.80
autophagy pathway	participates_in	pathway	0.80
MTOR	regulates	gene	0.80
MTORC1	regulates	gene	0.80
stem cells	expressed_in	cell_type	0.80
AUTOPHAGY	biomarker_for	process	0.80
neural stem cells	interacts_with	cell_type	0.80
Autophagy	interacts_with	pathway	0.80
Autophagy	associated_with	pathway	0.80
Mtor	associated_with	pathway	0.80
P62	activates	gene	0.80
Mitophagy	activates	pathway	0.80
CANCER	associated_with	gene	0.80
Tumor	associated_with	disease	0.75
Neurodegeneration	activates	disease	0.75
Als	activates	disease	0.75
SQSTM1	activates	gene	0.70
MTOR	associated_with	gene	0.70
ATG	associated_with	gene	0.70
Apoptosis	associated_with	pathway	0.70
GENES	activates	gene	0.70
MTOR	activates	gene	0.70
Mtor	activates	pathway	0.70
AKT	activates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
MTORC1	associated_with	gene	0.70
UBIQUITIN	activates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
NBR1	activates	gene	0.70

Incoming (627)

Source	Relation	Type	Str
Acetylation	modulates	mechanism	0.95
ATG4B	substrate_of	protein	0.92
ATG12-ATG5-ATG16L1 COMPLEX	catalyzes	protein	0.90
BECN1	regulates	gene	0.90
LC3	regulates	gene	0.90
rapamycin	targets	drug	0.90
TGM2	binds	gene	0.90
Mc3R Agonists	upregulates	drug	0.90
AUTOPHAGY	activates	gene	0.90
MITOPHAGY	activates	gene	0.90
PARKIN	upstream_of	protein	0.87
PI3K-AKT	regulates	pathway	0.85
LYC	contributes_to	drug	0.80
AMPK	regulates	gene	0.80
ATG	regulates	gene	0.80
GAPDH	regulates	gene	0.80
CALCOCO2	regulates	gene	0.80
BECN1	activates	gene	0.80
ATG5	interacts_with	gene	0.70
SQSTM1	associated_with	gene	0.70
SRSF1	binds	protein	0.70
AUTOPHAGY	associated_with	gene	0.70
RIPK2	associated_with	gene	0.70
GFP	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
NEURODEGENERATION	activates	gene	0.70
DMSO	associated_with	gene	0.70
ATG	interacts_with	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
BECN1	associated_with	gene	0.70
PI3K	associated_with	gene	0.70
ACTB	regulates	gene	0.70
CREB	regulates	gene	0.70
LAMP1	regulates	gene	0.70
GFP	activates	gene	0.70
SQSTM1	interacts_with	gene	0.60
SDC1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
PTEN	activates	gene	0.60
GABARAP	associated_with	gene	0.60
SMN1	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
TSC2	activates	gene	0.60
EGF	associated_with	gene	0.60
ACOX1	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAP1LC3

Understanding Entity Pages

Summary

Wiki Pages (20)

Golgi Apparatus Stress Comparison Across Neurodegenerative Diseases

MAP1LC3A Gene

prdx6

TFEB Autophagy Pathway

Autophagy-Lysosomal Dysfunction Neurons

Autophagy and Mitophagy Therapeutics Investment Landscape

ATG4B — Autophagy Related 4B Cysteine Peptidase

macroautophagy-dysfunction-parkinsons

GABARAP Protein

Alpha-Synuclein Autophagy Clearance

ATG4B Protein — Autophagy Related 4B

ATG12 — Autophagy Related 12

payload-progranulin-restoration-therapy-ftd

Autophagic Cell Death Pathway in Neurodegeneration

SPG11 Cytoskeletal Protein

LC3 (MAP1LC3) Neurons