| Gene Symbol | ent-gene-257405c9 |
| Nuclear envelope dysfunction | Loss of nuclear integrity from tau pathology (AD), α-synuclein (PD), TDP-43 (ALS/FTD), or mHTT (HD) allows nuclear DNA to escape into the cytoplasm[@fang2023]. |
| Micronuclei formation | Chromosomal instability creates micronuclei whose envelopes rupture, releasing dsDNA that potently activates cGAS. Elevated in ALS and FTD[@xia2022]. |
| Genomic instability | Impaired DNA repair (known in HD, ALS) causes DNA damage accumulation, generating cytosolic DNA fragments[@wang2024]. |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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