mechanism 2,962 words KG: ent-gene-75b41c33 2026-04-01
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

Irisin (FNDC5) - Exercise-Induced Myokine for Neurodegeneration

🔬 Protein Info
Gene SymbolFNDC5
Full NameFibronectin Type III Domain Containing 5
Chromosome1p36.22
Functionis a gene located on chromosome 1p36.
Primary ExpressionSkeletal muscle (primary), hippocampus, cortex, heart
Amino Acids112 aa
PathwaysDna Repair, Dopamine Pathways, Inflammasome, Mapk, Mitophagy
UniProt IDQ8IZF6
NCBI Gene ID56852
Ensembl IDENSG00000100597
GeneCardsFNDC5
Human Protein AtlasFNDC5
Skeletal musclePrimary source during exercise
Cardiac muscleMinor contribution
BrainLow levels of FNDC5 expression in neurons
Associated DiseasesAlzheimer, Alzheimer'S Disease, Ataxia, DIABETES
InteractionsPLAU, CXCL10, CX3CL1, VIM, BDNF, FGF23
KG Connections277 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (2 edges)

ent-gene-75b41c33 data_in benchmark_ot_ad_answer_key:FNDC5
benchmark_ot_ad_answer_key:FNDC5 data_in ent-gene-75b41c33